Nalphin
Generic Name
Nalbuphine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nalphin 10 mg injection | ৳ 54.36 | N/A |
Description
Overview of the medicine
Nalphin 10 mg Injection is a potent analgesic used for the relief of moderate to severe pain. It can be used as a pre-operative sedative or as a supplement to balanced anesthesia, and for obstetrical analgesia during labor.
Uses & Indications
Dosage
Adults
Typically 10 mg/70 kg IV, IM, or SC, may be repeated every 3-6 hours as needed.
Elderly
Reduced doses should be considered for elderly patients.
Renal_impairment
Dosage reduction or extended dosing intervals may be necessary in patients with renal impairment.
How to Take
Administered intravenously (IV), intramuscularly (IM), or subcutaneously (SC).
Mechanism of Action
Nalbuphine hydrochloride acts as an agonist at kappa opioid receptors and as a partial agonist or antagonist at mu opioid receptors. This action provides analgesia.
Pharmacokinetics
Onset
IV: 2-3 minutes; IM/SC: less than 15 minutes.
Excretion
Mainly excreted in urine, with some in feces.
Half life
Approximately 5 hours.
Absorption
Rapidly absorbed after intramuscular or subcutaneous administration.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to nalbuphine or any component of the formulation
- Prevention of sudden withdrawal symptoms in patients dependent on full opioid agonists
Drug Interactions
Other Opioids
May reduce the efficacy of or precipitate withdrawal in patients receiving full opioid agonists.
CNS Depressants
Concurrent use with other central nervous system depressants (e.g., alcohol, benzodiazepines) may increase the risk of respiratory depression and profound sedation.
Storage
Store below 25°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of nalbuphine can result in respiratory depression. Management involves supportive care and the use of an opioid antagonist, such as naloxone.
Pregnancy & Lactation
Pregnancy Category C/B (depends on trimester). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. May cause neonatal opioid withdrawal syndrome if used late in pregnancy. Caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to nalbuphine or any component of the formulation
- Prevention of sudden withdrawal symptoms in patients dependent on full opioid agonists
Drug Interactions
Other Opioids
May reduce the efficacy of or precipitate withdrawal in patients receiving full opioid agonists.
CNS Depressants
Concurrent use with other central nervous system depressants (e.g., alcohol, benzodiazepines) may increase the risk of respiratory depression and profound sedation.
Storage
Store below 25°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of nalbuphine can result in respiratory depression. Management involves supportive care and the use of an opioid antagonist, such as naloxone.
Pregnancy & Lactation
Pregnancy Category C/B (depends on trimester). Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. May cause neonatal opioid withdrawal syndrome if used late in pregnancy. Caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years.
Availability
Available in hospitals and pharmacies
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Various clinical trials have been conducted to assess the efficacy and safety of nalbuphine, establishing its role as an effective analgesic.
Lab Monitoring
- Respiratory rate monitoring
- Oxygen saturation
- Sedation level
- Pain assessment
Doctor Notes
- Use nalbuphine cautiously in opioid-dependent patients as it may precipitate withdrawal syndrome.
- Monitor for respiratory depression, especially after the initial dose.
- Advise patients to avoid CNS depressants.
Patient Guidelines
- Avoid driving or operating machinery as it can cause drowsiness.
- Do not alter the dose without consulting your doctor.
- Contact your doctor immediately if severe side effects occur.
Missed Dose Advice
This medication is usually given as needed or on a scheduled basis. If a dose is missed and the next dose is not due soon, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose. Do not double the dose.
Driving Precautions
Nalphin Injection can cause drowsiness, dizziness, and blurred vision, which may impair your ability to drive or operate machinery. You should not drive or perform hazardous tasks while on this medication.
Lifestyle Advice
- Avoid alcohol consumption.
- Refrain from activities requiring mental alertness.
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