Napa, Ace, Xcel
Generic Name
Daparol
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Description
Overview of the medicine
Daparol is an analgesic (pain reliever) and antipyretic (fever reducer) medication used to treat mild to moderate pain and fever. It acts primarily in the central nervous system.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed, not exceeding 4000 mg (4g) in 24 hours.
Elderly
Similar to adult dosage; caution and dose adjustment may be necessary in patients with impaired renal or hepatic function.
Renal_impairment
Dose reduction or extended dosing intervals may be required; consult a physician.
How to Take
For oral administration. May be taken with or without food. Tablets should be swallowed whole with water.
Mechanism of Action
Daparol's exact mechanism of action is not fully understood, but it is believed to act predominantly in the central nervous system, inhibiting prostaglandin synthesis. It exhibits weak anti-inflammatory effects.
Pharmacokinetics
Onset
Onset of action for pain relief is usually within 30-60 minutes.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates.
Half life
Plasma half-life is typically 1 to 4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, with a small amount metabolized via the cytochrome P450 pathway.
Side Effects
Contraindications
- Hypersensitivity to Daparol or any of its excipients
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity, especially with chronic excessive alcohol intake.
Warfarin
May enhance the anticoagulant effect, increasing risk of bleeding.
Isoniazid
Increased risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe hepatic necrosis. Symptoms include nausea, vomiting, abdominal pain, and sweating, which may appear 24-48 hours after ingestion. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine.
Pregnancy & Lactation
Considered generally safe for use during pregnancy and lactation at recommended doses. Always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Daparol or any of its excipients
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity, especially with chronic excessive alcohol intake.
Warfarin
May enhance the anticoagulant effect, increasing risk of bleeding.
Isoniazid
Increased risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe hepatic necrosis. Symptoms include nausea, vomiting, abdominal pain, and sweating, which may appear 24-48 hours after ingestion. Management involves gastric lavage, activated charcoal, and administration of N-acetylcysteine.
Pregnancy & Lactation
Considered generally safe for use during pregnancy and lactation at recommended doses. Always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, depending on the formulation and packaging.
Availability
Available in pharmacies and supermarkets
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials and post-marketing surveillance have established Daparol's efficacy and safety profile over decades of use.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of chronic use or suspected overdose.
- Renal function tests if there is pre-existing kidney impairment or chronic high-dose use.
Doctor Notes
- Advise patients on maximum daily dose and risks of concomitant use with other Daparol-containing products.
- Caution in patients with pre-existing liver or kidney conditions.
- Educate patients on symptoms of overdose and need for urgent medical attention.
Patient Guidelines
- Do not exceed the recommended dose to avoid serious liver damage.
- Avoid taking other Daparol-containing products simultaneously.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Daparol is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid such activities.
Lifestyle Advice
- Ensure adequate hydration while taking this medication, especially during fever.
- Limit alcohol intake, as it can increase the risk of liver damage.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.