Napa Rapid (Actizorb)
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napa rapid actizorb 500 mg tablet | ৳ 1.30 | ৳ 13.00 |
Description
Overview of the medicine
Napa Rapid Actizorb 500 mg Tablet is a fast-acting formulation of Paracetamol, designed for quick relief from pain and fever. The Actizorb technology facilitates rapid absorption, leading to a quicker onset of action compared to standard paracetamol tablets.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4 to 6 hours as needed. Maximum 4000 mg (8 tablets) in 24 hours.
Elderly
No specific dose adjustment is required, but caution is advised in patients with impaired renal or hepatic function.
Renal_impairment
Dose interval should be extended in severe renal impairment (e.g., 500 mg every 6-8 hours for CrCl 10-50 mL/min, and every 8 hours for CrCl <10 mL/min).
How to Take
Take orally with a glass of water, with or without food. Do not exceed the recommended dose or frequency.
Mechanism of Action
Paracetamol (Acetaminophen) primarily acts by inhibiting prostaglandin synthesis, mainly in the central nervous system (CNS). It exhibits analgesic and antipyretic effects by reducing the production of prostaglandins that sensitize pain receptors and mediate fever in the hypothalamus. The 'Actizorb' technology enhances tablet disintegration and dissolution, leading to faster absorption and a quicker onset of action.
Pharmacokinetics
Onset
Within 15-30 minutes for analgesic and antipyretic effects due to rapid absorption.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is typically 1 to 4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, especially with Actizorb formulation. Peak plasma concentrations are achieved faster (typically within 15-30 minutes) than conventional paracetamol.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 enzymes to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is normally detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic alcohol consumption.
Cholestyramine
Reduces paracetamol absorption if taken within one hour.
Warfarin and other coumarins
May enhance the anticoagulant effect, increasing the risk of bleeding with prolonged regular use.
Metoclopramide or Domperidone
May increase the rate of paracetamol absorption.
Certain antiepileptics (e.g., phenobarbital, phenytoin, carbamazepine)
May increase the risk of paracetamol-induced liver toxicity due to increased formation of toxic metabolites.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal, liver damage. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite. Immediate medical attention is crucial. N-acetylcysteine (NAC) is the antidote, most effective when administered within 8 hours of ingestion.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended therapeutic doses. It crosses the placental barrier and is excreted in breast milk in small amounts. However, consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic alcohol consumption.
Cholestyramine
Reduces paracetamol absorption if taken within one hour.
Warfarin and other coumarins
May enhance the anticoagulant effect, increasing the risk of bleeding with prolonged regular use.
Metoclopramide or Domperidone
May increase the rate of paracetamol absorption.
Certain antiepileptics (e.g., phenobarbital, phenytoin, carbamazepine)
May increase the risk of paracetamol-induced liver toxicity due to increased formation of toxic metabolites.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal, liver damage. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite. Immediate medical attention is crucial. N-acetylcysteine (NAC) is the antidote, most effective when administered within 8 hours of ingestion.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended therapeutic doses. It crosses the placental barrier and is excreted in breast milk in small amounts. However, consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3 years from manufacturing date.
Availability
Pharmacies, drugstores across Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic (Patent Expired)
WHO Essential Medicine
YesClinical Trials
As a well-established generic drug, large-scale clinical trials for general efficacy are not current. However, specific trials for 'Actizorb' formulation would have focused on demonstrating faster absorption and onset of action compared to standard paracetamol.
Lab Monitoring
- Liver function tests (especially in prolonged use, high doses, or suspected overdose)
- Renal function tests (in patients with pre-existing renal impairment)
Doctor Notes
- Emphasize strict adherence to dosing limits to prevent hepatotoxicity.
- Counsel patients to check other OTC products for paracetamol content to avoid accidental overdose.
- Advise caution in patients with pre-existing liver or kidney disease, or chronic alcohol users.
Patient Guidelines
- Do not exceed the stated dose.
- Do not take with other paracetamol-containing products.
- Consult a doctor if symptoms persist for more than 3 days (fever) or 5 days (pain).
- Avoid alcohol while taking this medicine, especially with high doses.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Paracetamol is generally not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Get sufficient rest.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.