Take with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break.

Naproxen works by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins from arachidonic acid. Prostaglandins are mediators of inflammation, pain, and fever. By inhibiting their synthesis, naproxen reduces these symptoms.

• •Hypersensitivity to naproxen or other NSAIDs
• •Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
• •Perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
• •Active gastrointestinal bleeding or ulcer
• •Severe renal or hepatic impairment
• •Third trimester of pregnancy

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Symptoms include drowsiness, heartburn, indigestion, nausea, vomiting, abdominal pain. Severe cases may involve gastrointestinal bleeding, acute renal failure, hypertension, respiratory depression, and coma. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingestion is recent.

Avoid use in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use during the first and second trimesters only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Naproxen is excreted in breast milk; use with caution in nursing mothers, or consider an alternative.