Napren
Generic Name
Naproxen
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napren 500 mg tablet | ৳ 9.03 | ৳ 54.18 |
Description
Overview of the medicine
Napren (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and fever. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
For mild to moderate pain, initial dose 500 mg, followed by 250 mg every 6-8 hours as needed. For chronic conditions like arthritis, 250-500 mg twice daily. Maximum daily dose 1250 mg.
Elderly
Lower doses may be required due to increased risk of side effects. Start with the lowest effective dose.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with mild to moderate renal impairment. Contraindicated in severe renal failure.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow whole with a glass of water.
Mechanism of Action
Naproxen inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By inhibiting their synthesis, naproxen reduces these symptoms.
Pharmacokinetics
Onset
Pain relief typically within 1 hour, anti-inflammatory effects may take longer.
Excretion
Primarily excreted in the urine (about 95%) as naproxen and its metabolites.
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver by demethylation and subsequent conjugation.
Side Effects
Contraindications
- Known hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma)
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
Diuretics (e.g., furosemide)
Reduced diuretic effect, increased risk of renal impairment.
Anticoagulants (e.g., warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of GI bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Should be avoided in the third trimester due to potential fetal harm. Small amounts are excreted in breast milk; use with caution or consider alternatives during lactation.
Side Effects
Contraindications
- Known hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma)
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
Diuretics (e.g., furosemide)
Reduced diuretic effect, increased risk of renal impairment.
Anticoagulants (e.g., warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of GI bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Should be avoided in the third trimester due to potential fetal harm. Small amounts are excreted in breast milk; use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent, Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established naproxen's efficacy and safety for its approved indications.
Patient Guidelines
- Take with food or milk to prevent stomach upset.
- Do not exceed the prescribed dose.
- Avoid alcohol while taking this medicine.
- Report any signs of unusual bleeding, severe stomach pain, or black stools to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness. Patients should be advised to exercise caution when driving or operating machinery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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