Naptodin Plus
Generic Name
Naproxen + Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| naptodin plus 500 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Naptodin Plus is a combination medicine containing Naproxen, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole, a proton pump inhibitor (PPI). It is used to relieve pain and inflammation while protecting the stomach lining from potential side effects of Naproxen.
Uses & Indications
Dosage
Adults
One tablet once daily, preferably before a meal, for the shortest duration possible.
Elderly
Use lowest effective dose for shortest duration. Close monitoring for adverse effects.
Renal_impairment
Use with caution. Dosage adjustment may be required in severe impairment.
How to Take
Take the tablet whole with water. Do not crush, chew, or split the tablet. Administer at least 30 minutes before a meal.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. Esomeprazole selectively inhibits the H+/K+-ATPase proton pump in gastric parietal cells, blocking the final step of acid secretion, leading to reduced gastric acidity.
Pharmacokinetics
Onset
Pain relief from Naproxen within 1-2 hours. Acid suppression from Esomeprazole within 1 hour.
Excretion
Mainly excreted in urine, some in feces.
Half life
Naproxen: approximately 12-17 hours. Esomeprazole: approximately 1.5 hours.
Absorption
Naproxen is rapidly and completely absorbed from the GI tract. Esomeprazole is also rapidly absorbed, but bioavailability increases with repeated dosing.
Metabolism
Both are primarily metabolized in the liver by CYP enzymes, Naproxen mainly by CYP2C9, Esomeprazole mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Naproxen, Esomeprazole, or other NSAIDs
- Active gastrointestinal bleeding or ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Digoxin
Increased digoxin levels.
Lithium
Increased lithium levels.
Tacrolimus
Increased risk of nephrotoxicity.
Clopidogrel
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE inhibitors
Reduced efficacy and increased risk of renal impairment.
SSRIs (e.g., Citalopram, Fluoxetine)
Increased risk of GI bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, GI bleeding. Management includes symptomatic and supportive care. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in other trimesters if benefits outweigh risks. Naproxen is excreted in breast milk; Esomeprazole may also be present. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Naproxen, Esomeprazole, or other NSAIDs
- Active gastrointestinal bleeding or ulcer
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Digoxin
Increased digoxin levels.
Lithium
Increased lithium levels.
Tacrolimus
Increased risk of nephrotoxicity.
Clopidogrel
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE inhibitors
Reduced efficacy and increased risk of renal impairment.
SSRIs (e.g., Citalopram, Fluoxetine)
Increased risk of GI bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, GI bleeding. Management includes symptomatic and supportive care. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in other trimesters if benefits outweigh risks. Naproxen is excreted in breast milk; Esomeprazole may also be present. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy of Naproxen in pain and inflammation, and Esomeprazole in gastric acid suppression and ulcer prevention. Combination studies support the co-administration for GI protection.
Lab Monitoring
- Complete blood count (CBC)
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Fecal occult blood test (FOBT) if GI symptoms occur.
Doctor Notes
- Consider individual patient risk factors for GI and cardiovascular events.
- Prescribe the lowest effective dose for the shortest duration necessary.
- Monitor patients on long-term therapy for potential adverse effects, including renal function and bone mineral density (for PPIs).
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any signs of unusual bleeding, severe stomach pain, or black/tarry stools.
- Avoid concomitant use with other NSAIDs or aspirin.
- Do not stop taking without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or blurred vision. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption.
- Quit smoking.
- Maintain a healthy diet to support GI health.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.