Napxon
Generic Name
Naproxen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napxon 375 mg tablet | ৳ 11.00 | ৳ 88.00 |
| napxon 500 mg tablet | ৳ 13.00 | ৳ 104.00 |
Description
Overview of the medicine
Napxon (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and to reduce inflammation. It is effective in treating conditions like arthritis, muscle aches, and menstrual pain.
Uses & Indications
Dosage
Adults
Typically 250-500 mg twice daily, or 750-1000 mg once daily for sustained-release formulations. Max 1000 mg/day (acute), 1500 mg/day (short-term for acute pain).
Elderly
Lower doses may be required due to increased risk of adverse effects, generally not exceeding 750 mg/day.
Renal_impairment
Adjust dosage; avoid in severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take with food or milk to reduce gastrointestinal upset. Swallow whole with a glass of water; do not crush or chew sustained-release tablets.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to decreased prostaglandin synthesis. Prostaglandins are involved in pain, inflammation, and fever.
Pharmacokinetics
Onset
About 1 hour
Excretion
Primarily via urine (approx. 95%), with a small amount in feces.
Half life
Approximately 12-17 hours
Absorption
Rapidly and completely absorbed from the GI tract. Peak plasma levels are reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma levels
Methotrexate
Increased methotrexate toxicity
Corticosteroids
Increased risk of GI ulceration/bleeding
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding
Diuretics, ACE inhibitors, ARBs
Reduced antihypertensive effect and increased risk of renal impairment
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain. Severe overdose can lead to GI bleeding, kidney failure, respiratory depression, coma. Management involves symptomatic and supportive care, gastric lavage, activated charcoal.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution during first and second trimesters, only if potential benefit outweighs risk. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of naproxen for its indicated uses across various populations.
Lab Monitoring
- Renal function (BUN, creatinine)
- Liver function (ALT, AST)
- Complete blood count (CBC) for signs of GI bleeding or anemia
- Blood pressure monitoring
Patient Guidelines
- Do not exceed recommended dose.
- Report any signs of GI bleeding (black stools, vomiting blood).
- Inform your doctor about all other medications you are taking, especially blood thinners or steroids.
- Avoid taking other NSAIDs concurrently.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's close to your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; use caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it can increase the risk of stomach irritation.
- Maintain a healthy diet and hydration.
- Limit exposure to sunlight as Naproxen can increase photosensitivity.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.