Nasox
Generic Name
Naproxen
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nasox 500 mg tablet | ৳ 3.88 | N/A |
Description
Overview of the medicine
Nasox 500 mg tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions like arthritis, menstrual pain, and muscle aches.
Uses & Indications
Dosage
Adults
For mild to moderate pain, dysmenorrhea, or acute tendinitis/bursitis: 500 mg initially, followed by 250 mg every 6-8 hours as needed. Maximum daily dose: 1250 mg. For chronic conditions like arthritis: 250 mg to 500 mg twice daily.
Elderly
Use the lowest effective dose for the shortest duration. Monitor for adverse effects, especially gastrointestinal and renal.
Renal_impairment
Dosage reduction may be necessary. Not recommended for severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water, do not crush or chew.
Mechanism of Action
Naproxen works by inhibiting the activity of cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually within 1 hour; anti-inflammatory effects may take longer, up to 1-2 weeks for full effect in chronic conditions.
Excretion
Primarily excreted in the urine (approximately 95% as naproxen, 6-O-desmethylnaproxen, and their conjugates).
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations occur within 2-4 hours.
Metabolism
Extensively metabolized in the liver to 6-O-desmethylnaproxen, primarily via CYP2C9 and CYP2C18, and subsequently glucuronidated.
Side Effects
Contraindications
- •Hypersensitivity to naproxen, aspirin, or other NSAIDs
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Active gastrointestinal bleeding or peptic ulcer disease
- •Severe heart failure
- •Severe renal impairment
- •Third trimester of pregnancy
- •Coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased lithium plasma levels and toxicity.
Methotrexate
Increased methotrexate plasma levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect; increased risk of renal impairment.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, indigestion, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C in first and second trimesters, D in third trimester. Avoid use in late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Consult doctor. Small amounts may pass into breast milk; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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