Naspro Plus
Generic Name
Naproxen + Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| naspro plus 500 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Naspro Plus 500 mg Tablet is a combination medicine containing Naproxen, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole, a proton pump inhibitor (PPI). It is used to relieve pain, inflammation, and stiffness caused by various conditions like arthritis, while also protecting the stomach from the side effects of Naproxen.
Uses & Indications
Dosage
Adults
The usual recommended dose is one tablet (Naproxen 500 mg/Esomeprazole 20 mg) twice daily, or as directed by the physician. It should be taken at least 30 minutes before meals.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution should be exercised due to potential age-related decrease in renal or hepatic function. Consider the lowest effective dose for the shortest duration.
Renal_impairment
Use with caution in patients with mild to moderate renal impairment. Avoid in severe renal impairment. A significant dose reduction may be necessary, and renal function should be closely monitored.
How to Take
Take the tablet whole with a glass of water, at least 30 minutes before a meal. Do not crush, chew, or split the tablet.
Mechanism of Action
Naproxen works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins, chemicals that cause pain and inflammation. Esomeprazole reduces gastric acid secretion by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, thereby decreasing acid production and providing protection against NSAID-induced ulcers.
Pharmacokinetics
Onset
Naproxen: Analgesic effect typically within 1-2 hours. Esomeprazole: Acid suppression within 1 hour.
Excretion
Naproxen and its metabolites are primarily excreted in the urine. Esomeprazole metabolites are primarily excreted through the kidneys (80%) and in the feces (20%).
Half life
Naproxen: 12-17 hours. Esomeprazole: Approximately 1-1.5 hours.
Absorption
Naproxen is rapidly and completely absorbed from the GI tract. Esomeprazole is rapidly absorbed, with bioavailability increasing to approximately 90% after repeated doses.
Metabolism
Naproxen is primarily metabolized in the liver by CYP450 enzymes. Esomeprazole is extensively metabolized in the liver via the cytochrome P450 system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- •Hypersensitivity to naproxen, esomeprazole, or any component of the formulation.
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- •Active gastrointestinal bleeding or peptic ulcer.
- •Severe renal or hepatic impairment.
- •Third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus.
- •Patients with severe heart failure (NYHA Class III-IV).
Drug Interactions
Digoxin
Increased digoxin plasma levels.
Lithium
Increased lithium plasma levels and potential for toxicity.
Rifampicin
May decrease plasma levels of esomeprazole.
Clopidogrel
Increased bleeding risk.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Atazanavir/Nelfinavir
Reduced absorption of antiretroviral agents; avoid concomitant use.
Warfarin/Anticoagulants
Increased risk of bleeding.
Ketoconazole/Itraconazole
Reduced absorption of antifungals due to increased gastric pH.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, gastrointestinal bleeding, disorientation, excitation, coma, anaphylactoid reactions, hypertension, acute renal failure, and respiratory depression. Treatment is supportive and symptomatic; gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy: Category C. Avoid in the third trimester due to risk of premature closure of fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit outweighs the potential risk to the fetus. Lactation: Both naproxen and esomeprazole are excreted in breast milk. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved in Bangladesh
Patent Status
Off-patent (active ingredients)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in