Natagen
Generic Name
Tocotrienol & Tocopherol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| natagen 5 suspension | ৳ 100.30 | N/A |
Description
Overview of the medicine
Natagen is a Vitamin E preparation containing Tocotrienol and Tocopherol, acting as a powerful antioxidant to protect cells from damage and support overall health.
Uses & Indications
Dosage
Adults
Typically 200-400 mg of Tocotrienols/Tocopherols once daily, or as directed by physician.
Elderly
Same as adult dose, adjust for renal/hepatic impairment if necessary.
Renal_impairment
No specific dose adjustment necessary for mild to moderate impairment, use with caution in severe cases.
How to Take
To be taken orally, preferably with a meal to enhance absorption.
Mechanism of Action
Tocotrienols and Tocopherols are lipid-soluble antioxidants that scavenge free radicals, preventing oxidative stress and lipid peroxidation in cell membranes.
Pharmacokinetics
Onset
Effects are generally long-term; antioxidant effects build up over weeks.
Excretion
Excreted primarily through bile and feces, with some renal excretion.
Half life
Varies, typically 10-20 hours for Tocopherol. Tocotrienols might have shorter half-lives.
Absorption
Well absorbed from the gastrointestinal tract, especially with fatty meals.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Caution in patients taking anticoagulants due to potential increased bleeding risk at very high doses.
Drug Interactions
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effect, increasing bleeding risk at very high doses of Vitamin E.
Cholestyramine, Colestipol, Orlistat
May reduce absorption of fat-soluble vitamins including Vitamin E.
Storage
Store below 30°C, away from light and moisture.
Overdose
Overdose is rare, but very high doses may lead to gastrointestinal disturbances, fatigue, weakness, or increased bleeding risk in susceptible individuals. Symptomatic and supportive treatment.
Pregnancy & Lactation
Generally considered safe within recommended dietary allowances. High doses should be used with caution and under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Caution in patients taking anticoagulants due to potential increased bleeding risk at very high doses.
Drug Interactions
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effect, increasing bleeding risk at very high doses of Vitamin E.
Cholestyramine, Colestipol, Orlistat
May reduce absorption of fat-soluble vitamins including Vitamin E.
Storage
Store below 30°C, away from light and moisture.
Overdose
Overdose is rare, but very high doses may lead to gastrointestinal disturbances, fatigue, weakness, or increased bleeding risk in susceptible individuals. Symptomatic and supportive treatment.
Pregnancy & Lactation
Generally considered safe within recommended dietary allowances. High doses should be used with caution and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
No longer patented (generic available)
Clinical Trials
Extensive research exists on Vitamin E (Tocopherols and Tocotrienols) for its antioxidant and various health benefits.
Lab Monitoring
- No routine lab monitoring required.
- Monitor INR/PT in patients on anticoagulants if high doses of Vitamin E are initiated.
Doctor Notes
- Advise patients about the importance of a balanced diet alongside supplementation.
- Caution patients on anticoagulants about potential interaction at high doses.
Patient Guidelines
- Take as directed by your physician or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in antioxidants.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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