Natrilix SR
Generic Name
Indapamide Sustained Release
Manufacturer
Servier
Country
France
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| natrilix sr 15 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Indapamide SR is a thiazide-like diuretic primarily used to treat essential hypertension. It works by increasing the excretion of sodium and water from the body, thereby reducing blood volume and blood pressure. The sustained-release formulation ensures a prolonged effect, allowing for once-daily dosing.
Uses & Indications
Dosage
Adults
The usual dose is one 1.5 mg tablet once daily, preferably in the morning. The maximum daily dose is 1.5 mg.
Elderly
No specific dose adjustment is generally required for elderly patients. However, close monitoring of renal function and electrolyte levels is advisable.
Renal_impairment
No dose adjustment is necessary for mild to moderate renal impairment (creatinine clearance ≥ 30 ml/min). Indapamide SR is contraindicated in severe renal failure (creatinine clearance < 30 ml/min).
How to Take
Take the tablet orally, preferably in the morning. Swallow the tablet whole with water, do not chew or crush it. It can be taken with or without food.
Mechanism of Action
Indapamide acts primarily in the cortical diluting segment of the kidney, where it inhibits the reabsorption of sodium and chloride. This leads to increased excretion of sodium, chloride, and water, resulting in diuresis and a reduction in blood volume. Additionally, it has a direct vascular effect, reducing peripheral vascular resistance.
Pharmacokinetics
Onset
Diuretic effect onset within 1-2 hours. Full antihypertensive effect may take several days to weeks to manifest.
Excretion
Approximately 70% of the dose is eliminated via urine and 20-23% via feces in the form of inactive metabolites.
Half life
Approximately 14 to 24 hours, allowing for once-daily administration.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached about 12 hours after administration of the sustained-release tablet.
Metabolism
Extensively metabolized in the liver, with less than 5% excreted unchanged in urine.
Side Effects
Contraindications
- •Hypersensitivity to indapamide, other sulfonamides, or any excipients of the tablet.
- •Severe renal failure (creatinine clearance < 30 ml/min).
- •Hepatic encephalopathy or severe hepatic impairment.
- •Hypokalemia.
- •Lactation.
Drug Interactions
Digoxin
Hypokalemia induced by indapamide increases the risk of digitalis toxicity.
Lithium
Increased plasma lithium levels with signs of overdose (due to reduced renal clearance of lithium).
NSAIDs (e.g., ibuprofen, diclofenac)
May reduce the antihypertensive effect of indapamide and increase the risk of acute renal failure, especially in dehydrated patients.
Antidepressants (tricyclic antidepressants, neuroleptics)
Increased antihypertensive effect and risk of orthostatic hypotension.
Potassium-depleting drugs (e.g., corticosteroids, amphotericin B, stimulating laxatives)
Increased risk of hypokalemia.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include nausea, vomiting, weakness, electrolyte disturbances (hypokalemia, hyponatremia), and profound diuresis leading to dehydration and hypotension. Treatment involves gastric lavage/emesis, correction of fluid and electrolyte imbalances. Symptomatic and supportive treatment should be provided.
Pregnancy & Lactation
Not recommended during pregnancy unless strictly essential, due to potential risks of fetal jaundice, thrombocytopenia, and effects on electrolyte balance. Indapamide is excreted in breast milk, so avoid during lactation or discontinue breastfeeding while on treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, specific details on packaging.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Expired
WHO Essential Medicine
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Global Brand Names
International brand names for this medicine
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