Navix-Plus
Generic Name
Clopidogrel 75 mg & Aspirin 75 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| navix plus 75 mg tablet | ৳ 12.07 | ৳ 120.67 |
Description
Overview of the medicine
Navix-Plus 75 mg Tablet is a combination antiplatelet medication containing Clopidogrel and Aspirin (acetylsalicylic acid). It is primarily used to prevent blood clots in patients who have had a heart attack, stroke, or who suffer from peripheral arterial disease, thereby reducing the risk of further cardiovascular events.
Uses & Indications
Dosage
Adults
Acute Coronary Syndrome (Unstable Angina/NSTEMI or STEMI): Usually one tablet (Clopidogrel 75 mg and Aspirin 75 mg) once daily, after an initial loading dose of Clopidogrel (300 mg) and Aspirin (150-300 mg) as advised by physician. Established Atherothrombotic Disease: One tablet (Clopidogrel 75 mg and Aspirin 75 mg) once daily.
Elderly
No dosage adjustment is generally required for elderly patients, but caution is advised due to increased risk of bleeding.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment. Caution is advised in severe renal impairment due to potential for increased Aspirin exposure and bleeding risk.
How to Take
Oral administration. Take the tablet with or without food, preferably at the same time each day. Do not crush or chew the tablet, swallow it whole with water.
Mechanism of Action
Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor, preventing ADP-mediated platelet activation and aggregation. Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, thereby blocking the synthesis of thromboxane A2 (TXA2), a potent inducer of platelet aggregation and vasoconstriction.
Pharmacokinetics
Onset
Clopidogrel: Antiplatelet effect within 2 hours, maximal within 3-7 days. Aspirin: Rapid antiplatelet effect, within 30-60 minutes.
Excretion
Clopidogrel metabolites are excreted primarily via urine and feces. Aspirin (as salicylic acid and its metabolites) is primarily excreted via the kidneys.
Half life
Clopidogrel (active metabolite): Approximately 8 hours. Aspirin: 15-20 minutes (parent drug), salicylic acid (active metabolite): 2-4 hours.
Absorption
Clopidogrel is rapidly absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism. Aspirin is rapidly and completely absorbed from the GI tract.
Metabolism
Clopidogrel is a prodrug, metabolized primarily by CYP450 enzymes (mainly CYP2C19) to its active metabolite and inactive carboxylic acid derivatives. Aspirin is rapidly hydrolyzed to salicylic acid by esterases in the GI mucosa, liver, and plasma.
Side Effects
Contraindications
- •Hypersensitivity to Clopidogrel, Aspirin, or any component of the tablet.
- •Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
- •Severe hepatic impairment.
- •Severe renal impairment (especially with Aspirin).
- •Patients with asthma, rhinitis, and nasal polyps due to risk of aspirin-induced asthma.
- •Children and adolescents under 16 years of age (due to risk of Reye's syndrome with Aspirin).
Drug Interactions
SSRIs/SNRIs
Increased risk of bleeding.
Metamizole (dipyrone)
May reduce the antiplatelet effect of Aspirin when taken concomitantly.
NSAIDs (e.g., ibuprofen, naproxen)
Increased risk of gastrointestinal bleeding and ulceration. Also, NSAIDs may reduce the antiplatelet effect of Aspirin.
Warfarin, Heparin, other anticoagulants
Increased risk of bleeding.
Proton Pump Inhibitors (e.g., Omeprazole, Esomeprazole)
May reduce the antiplatelet effect of Clopidogrel by inhibiting CYP2C19.
Drugs metabolized by CYP2C19 (e.g., phenytoin, tolbutamide)
Potential for altered drug levels.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Clopidogrel overdose include prolonged bleeding time and possible bleeding complications. Aspirin overdose symptoms include tinnitus, vertigo, headache, nausea, vomiting, confusion, hyperthermia, dehydration, hyperventilation, respiratory alkalosis, metabolic acidosis, and cardiovascular collapse. Management involves symptomatic and supportive care, gastric decontamination, and correction of fluid/electrolyte imbalances. Vitamin K or platelet transfusions may be considered for severe bleeding with Clopidogrel. For Aspirin, forced alkaline diuresis or hemodialysis may be necessary.
Pregnancy & Lactation
Pregnancy: Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus (e.g., premature closure of ductus arteriosus, increased bleeding risk). Only use if potential benefit outweighs the risk. Lactation: Both Clopidogrel and Aspirin (salicylic acid) are excreted in breast milk. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date, check specific packaging.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities (e.g., DGDA in Bangladesh)
Patent Status
Generically available; original patents expired for individual components
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in