Naxsil
Generic Name
Naproxen Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| naxsil 500 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Naxsil 500 mg Tablet contains Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), used for pain relief, reduction of inflammation, and fever.
Uses & Indications
Dosage
Adults
Usually 250-500 mg twice daily. For acute pain, an initial dose of 500 mg followed by 250 mg every 6-8 hours as needed, not exceeding 1250 mg on the first day and 1000 mg per day thereafter.
Elderly
Lower doses may be required due to increased risk of adverse effects. Close monitoring is recommended.
Renal_impairment
Dose adjustment may be necessary. Use with caution in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow whole with water.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually within 1 hour.
Excretion
Mainly excreted in the urine as naproxen, its metabolites, and conjugates (about 95%).
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver to 6-O-desmethylnaproxen, then conjugated with glucuronic acid.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs (e.g., aspirin)
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs/Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, heartburn, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within the first few hours.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution during early pregnancy only if clearly needed. Excreted in breast milk, use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies and Hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of naproxen for various inflammatory and pain conditions. Ongoing research continues to explore its long-term effects and comparative efficacy with newer NSAIDs.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN) in long-term use or in patients with renal impairment.
- Liver function tests (ALT, AST) periodically, especially in patients with pre-existing liver conditions.
- Complete blood count (CBC) to check for anemia or other blood dyscrasias, especially with long-term use.
Doctor Notes
- Consider lowest effective dose for shortest duration to minimize risks.
- Regularly assess GI and cardiovascular risk factors, especially in elderly patients or those with a history of such conditions.
- Prescribe with a proton pump inhibitor (PPI) if GI risk is high.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about any pre-existing medical conditions or other medications you are taking.
- Report any signs of gastrointestinal bleeding (black, tarry stools; vomiting blood) or allergic reactions immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid alcohol while taking this medicine to reduce the risk of stomach bleeding.
- Discuss long-term use with your doctor, as NSAIDs can have cardiovascular and gastrointestinal risks.
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Global Brand Names
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