Nebanol-Plus
Generic Name
nebanol-plus-35-mg-ointment
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nebanol plus 35 mg ointment | ৳ 30.20 | N/A |
Description
Overview of the medicine
Nebanol-Plus ointment is a topical antibiotic combination typically containing Neomycin Sulfate (e.g., 3.5 mg/g) and Bacitracin Zinc (e.g., 500 units/g). It is used to prevent and treat minor skin infections, cuts, scrapes, and burns caused by susceptible bacteria.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area 1 to 3 times daily, or as directed by a physician.
Elderly
No specific dose adjustment required; use as per adult dosage.
Renal_impairment
No specific dose adjustment required for topical use due to minimal systemic absorption, but caution with extensive use on compromised skin.
How to Take
For external use only. Clean the affected area thoroughly before application. Apply a small amount of ointment and gently rub it in. The treated area may be covered with a sterile dressing.
Mechanism of Action
Neomycin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Bacitracin inhibits bacterial cell wall synthesis. Together, they provide broad-spectrum bactericidal activity against susceptible Gram-positive and some Gram-negative bacteria.
Pharmacokinetics
Onset
Rapid onset of action locally after topical application.
Excretion
If systemically absorbed (which is rare), excreted primarily via kidneys.
Half life
Not systematically relevant due to minimal systemic absorption.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase if applied to large areas of abraded or damaged skin.
Metabolism
Not significantly metabolized systemically due to minimal absorption.
Side Effects
Contraindications
- Hypersensitivity to Neomycin, Bacitracin, Polymyxin B (if present), or any component of the formulation.
- Application to large areas of denuded skin, severe burns, or deep puncture wounds.
- Perforated eardrum, especially if applied to the ear canal.
Drug Interactions
Other Topical Preparations
Avoid applying other topical preparations to the same area simultaneously without consulting a doctor.
Systemic Nephrotoxic/Ototoxic Drugs
Although systemic absorption is minimal, extensive topical use on broken skin, especially with prolonged therapy, may increase the risk of systemic absorption of neomycin. Concurrent use of other nephrotoxic (e.g., aminoglycosides) or ototoxic drugs (e.g., loop diuretics) should be avoided or monitored closely.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Topical overdose is unlikely to cause acute systemic toxicity due to poor absorption. In case of accidental ingestion, gastrointestinal upset may occur. If significant systemic absorption is suspected (e.g., very large areas of broken skin treated extensively), monitor for signs of ototoxicity and nephrotoxicity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation should be undertaken with caution and only if clearly needed. While systemic absorption is generally minimal, the potential for neomycin ototoxicity in the fetus/infant exists with extensive or prolonged use on compromised skin. Consult a doctor. Avoid applying to the breast area during lactation to prevent infant exposure.
Side Effects
Contraindications
- Hypersensitivity to Neomycin, Bacitracin, Polymyxin B (if present), or any component of the formulation.
- Application to large areas of denuded skin, severe burns, or deep puncture wounds.
- Perforated eardrum, especially if applied to the ear canal.
Drug Interactions
Other Topical Preparations
Avoid applying other topical preparations to the same area simultaneously without consulting a doctor.
Systemic Nephrotoxic/Ototoxic Drugs
Although systemic absorption is minimal, extensive topical use on broken skin, especially with prolonged therapy, may increase the risk of systemic absorption of neomycin. Concurrent use of other nephrotoxic (e.g., aminoglycosides) or ototoxic drugs (e.g., loop diuretics) should be avoided or monitored closely.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Topical overdose is unlikely to cause acute systemic toxicity due to poor absorption. In case of accidental ingestion, gastrointestinal upset may occur. If significant systemic absorption is suspected (e.g., very large areas of broken skin treated extensively), monitor for signs of ototoxicity and nephrotoxicity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation should be undertaken with caution and only if clearly needed. While systemic absorption is generally minimal, the potential for neomycin ototoxicity in the fetus/infant exists with extensive or prolonged use on compromised skin. Consult a doctor. Avoid applying to the breast area during lactation to prevent infant exposure.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, specific to manufacturer guidelines.
Availability
Pharmacies and medical supply stores
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Off-patent
Clinical Trials
As a combination of well-established, older antibiotics, extensive new clinical trials for Nebanol-Plus are infrequent. Efficacy is supported by decades of clinical use and studies on its individual components against common skin pathogens.
Lab Monitoring
- Not routinely required for topical use. For extensive or prolonged use on compromised skin, especially in patients with impaired renal function, monitoring of renal function (e.g., serum creatinine, BUN) and audiometric testing may be considered if systemic absorption is a concern.
Doctor Notes
- Emphasize the importance of patient counseling regarding potential hypersensitivity reactions, especially to neomycin, which can develop with repeated use.
- Advise patients not to exceed the recommended duration of therapy (typically 7 days) without re-evaluation.
- Caution against use on large body surface areas, deep wounds, or in patients with pre-existing renal impairment without careful consideration of systemic absorption risk.
Patient Guidelines
- Apply only to the skin; do not ingest or use in the eyes, nose, or mouth.
- Wash hands before and after applying the ointment.
- Do not use for more than 7 days unless specifically directed by a healthcare professional.
- Discontinue use and consult a doctor if the skin condition worsens, irritation persists, or signs of superinfection appear.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Nebanol-Plus ointment, being a topical medication with minimal systemic absorption, is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene around the wound or affected area to prevent reinfection.
- Keep the treated area clean and dry.
- Avoid tight clothing over the treated area to allow air circulation.
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