Neobet
Generic Name
Betamethasone Valerate & Neomycin Sulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neobet 01 05 cream | ৳ 35.00 | N/A |
Description
Overview of the medicine
Neobet-01-05-cream is a combination medication containing a corticosteroid (Betamethasone Valerate) and an antibiotic (Neomycin Sulfate). It is used to treat inflammatory skin conditions that are complicated by secondary bacterial infections.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily. Do not use for more than 7 days without medical advice.
Elderly
No special dosage adjustment is generally required, but caution is advised due to potential thinning of skin and increased susceptibility to side effects.
Renal_impairment
No specific dosage adjustment for topical use; however, prolonged use over large areas, particularly with compromised skin, should be avoided due to potential systemic absorption of neomycin.
How to Take
For external use only. Apply a thin layer to the affected skin area and gently rub in. Wash hands before and after application. Avoid contact with eyes, nose, mouth, and other mucous membranes.
Mechanism of Action
Betamethasone Valerate is a potent corticosteroid that provides anti-inflammatory, antipruritic, and vasoconstrictive actions. Neomycin Sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, thereby exerting bactericidal effects against susceptible organisms.
Pharmacokinetics
Onset
Topical anti-inflammatory and antibacterial effects are generally rapid.
Excretion
Betamethasone: Metabolites are primarily excreted by the kidneys. Neomycin: If absorbed, primarily excreted unchanged by the kidneys.
Half life
Not typically reported for topical application due to minimal systemic absorption.
Absorption
Betamethasone: Minimal systemic absorption; absorption increases with occlusive dressings, skin inflammation, or extensive use. Neomycin: Poorly absorbed through intact skin, but absorption increases significantly with damaged or denuded skin.
Metabolism
Betamethasone: Primarily metabolized in the liver. Neomycin: Not significantly metabolized systemically following topical application.
Side Effects
Contraindications
- Hypersensitivity to betamethasone, neomycin, or any excipients.
- Viral infections of the skin (e.g., herpes simplex, varicella).
- Fungal infections of the skin.
- Perioral dermatitis, rosacea, acne vulgaris.
- Untreated bacterial infections.
- Widespread plaque psoriasis (due to potential for systemic absorption).
Drug Interactions
Systemic Aminoglycosides
If significant systemic absorption of neomycin occurs (e.g., from large areas of damaged skin), there is an increased risk of ototoxicity and nephrotoxicity when co-administered with other systemic aminoglycosides or other ototoxic/nephrotoxic drugs.
Corticosteroids (Systemic)
Concurrent use of systemic corticosteroids may increase the risk of systemic corticosteroid adverse effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely. However, prolonged or excessive use of corticosteroids may lead to systemic effects such as Cushing's syndrome, adrenal suppression, or features of hypercorticism. Excessive absorption of neomycin, especially from large areas of damaged skin, may lead to ototoxicity and nephrotoxicity.
Pregnancy & Lactation
Pregnancy: Use with caution during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Avoid extensive use or prolonged periods. Lactation: It is not known if topically applied corticosteroids or neomycin are excreted in human milk. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to betamethasone, neomycin, or any excipients.
- Viral infections of the skin (e.g., herpes simplex, varicella).
- Fungal infections of the skin.
- Perioral dermatitis, rosacea, acne vulgaris.
- Untreated bacterial infections.
- Widespread plaque psoriasis (due to potential for systemic absorption).
Drug Interactions
Systemic Aminoglycosides
If significant systemic absorption of neomycin occurs (e.g., from large areas of damaged skin), there is an increased risk of ototoxicity and nephrotoxicity when co-administered with other systemic aminoglycosides or other ototoxic/nephrotoxic drugs.
Corticosteroids (Systemic)
Concurrent use of systemic corticosteroids may increase the risk of systemic corticosteroid adverse effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely. However, prolonged or excessive use of corticosteroids may lead to systemic effects such as Cushing's syndrome, adrenal suppression, or features of hypercorticism. Excessive absorption of neomycin, especially from large areas of damaged skin, may lead to ototoxicity and nephrotoxicity.
Pregnancy & Lactation
Pregnancy: Use with caution during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Avoid extensive use or prolonged periods. Lactation: It is not known if topically applied corticosteroids or neomycin are excreted in human milk. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved for topical use
Patent Status
Generic
Clinical Trials
Extensive clinical experience exists for both Betamethasone and Neomycin as individual agents and in combination, supporting their efficacy and safety for indicated conditions.
Lab Monitoring
- Not routinely required for typical topical use. In cases of extensive, prolonged use, particularly in children or with occlusive dressings, monitoring for adrenal suppression may be considered.
Doctor Notes
- Emphasize short-term use (typically < 7 days) to minimize corticosteroid side effects and antibiotic resistance.
- Advise against use on the face or in intertriginous areas unless specifically indicated.
- Educate patients on proper application technique and warning signs of local/systemic adverse effects.
Patient Guidelines
- Use only as directed by your doctor.
- For external use only; do not ingest.
- Avoid contact with eyes, nose, mouth, and broken skin.
- Do not use on the face, groin, or axillae unless specifically instructed by a doctor.
- Do not use for more than 7 days without consulting your doctor.
- Do not cover the treated area with bandages or other occlusive dressings unless directed by a doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Neobet-01-05-cream is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene to prevent further infections. Avoid irritating soaps or cosmetics on affected areas.
- Wear loose-fitting clothing to allow air circulation to affected areas.
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