Neobetrin
Generic Name
Neobetrin 5 mg Ointment
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neobetrin 5 mg ointment | ৳ 44.00 | N/A |
Description
Overview of the medicine
Neobetrin 5 mg Ointment is a triple antibiotic formulation containing Neomycin Sulfate, Bacitracin Zinc, and Polymyxin B Sulfate. It is used to prevent and treat minor skin infections caused by bacteria, such as cuts, scrapes, and burns.
Uses & Indications
Dosage
Adults
Apply a small amount to the affected area 1 to 3 times daily, after cleaning the area.
Elderly
Same as adult dosage.
Renal_impairment
No specific dosage adjustment required for topical use due to minimal systemic absorption.
How to Take
For external use only. Clean the affected area thoroughly before applying a thin layer of ointment. May be covered with a sterile bandage.
Mechanism of Action
Neomycin binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Bacitracin inhibits bacterial cell wall synthesis. Polymyxin B disrupts the integrity of the bacterial outer membrane by binding to phospholipids, leading to cell leakage and death.
Pharmacokinetics
Onset
Within hours of application for antimicrobial action.
Excretion
Primarily through local action; minimal systemic excretion.
Half life
Not clinically significant due to minimal systemic absorption.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with compromised skin barrier (e.g., burns, severe dermatitis).
Metabolism
Not extensively metabolized systemically due to minimal absorption.
Side Effects
Contraindications
- Hypersensitivity to Neomycin, Bacitracin, Polymyxin B, or any component of the formulation.
- Deep or puncture wounds, animal bites, or serious burns.
Drug Interactions
Other topical agents
Avoid concomitant use with other topical medications on the same area unless directed by a doctor, as it may alter absorption or efficacy.
Nephrotoxic or Ototoxic Drugs (systemic)
Though systemic absorption is minimal, prolonged or extensive use, especially on compromised skin, could theoretically increase systemic absorption of neomycin, which is known for nephrotoxicity and ototoxicity. Caution with other nephrotoxic/ototoxic drugs.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic effects due to minimal absorption. Excessive application may lead to skin irritation. If ingested, seek medical attention.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and advised by a doctor. Minimal systemic absorption reduces risk, but caution is advised.
Side Effects
Contraindications
- Hypersensitivity to Neomycin, Bacitracin, Polymyxin B, or any component of the formulation.
- Deep or puncture wounds, animal bites, or serious burns.
Drug Interactions
Other topical agents
Avoid concomitant use with other topical medications on the same area unless directed by a doctor, as it may alter absorption or efficacy.
Nephrotoxic or Ototoxic Drugs (systemic)
Though systemic absorption is minimal, prolonged or extensive use, especially on compromised skin, could theoretically increase systemic absorption of neomycin, which is known for nephrotoxicity and ototoxicity. Caution with other nephrotoxic/ototoxic drugs.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic effects due to minimal absorption. Excessive application may lead to skin irritation. If ingested, seek medical attention.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and advised by a doctor. Minimal systemic absorption reduces risk, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, drugstores
Approval Status
Approved (Hypothetical)
Patent Status
Generic/Off-patent
Clinical Trials
No specific clinical trial information available for this hypothetical brand; efficacy is based on established active ingredients.
Lab Monitoring
- Not routinely required for topical use. Monitor for signs of skin irritation or sensitization.
Doctor Notes
- Advise patients on proper application technique and duration of use.
- Educate patients on potential signs of allergic reaction, especially to Neomycin.
- Consider alternative antibiotics if no improvement is seen after 7 days.
Patient Guidelines
- Wash hands before and after applying the ointment.
- Do not use for more than one week unless directed by a doctor.
- Avoid contact with eyes.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra ointment to make up for a missed dose.
Driving Precautions
Does not affect ability to drive or operate machinery.
Lifestyle Advice
- Keep the affected area clean and dry.
- Avoid scratching or irritating the wound.
- Wear loose clothing over the treated area.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.