Neoflam
Generic Name
Ibuprofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neoflam 400 mg tablet | ৳ 1.40 | ৳ 14.00 |
Description
Overview of the medicine
Neoflam 400 mg Tablet contains Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for headaches, menstrual pain, muscle aches, dental pain, and arthritic conditions.
Uses & Indications
Dosage
Adults
Typical oral dose for adults is 200-400 mg every 4-6 hours as needed. Maximum daily dose is generally 1200 mg for OTC use and up to 2400 mg for prescription use under medical supervision.
Elderly
Lower doses may be considered due to increased risk of adverse effects. Close monitoring for gastrointestinal and renal toxicity is recommended.
Renal_impairment
Use with caution; dose reduction may be necessary. Avoid in severe renal impairment.
How to Take
Take orally with a full glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet.
Mechanism of Action
Ibuprofen works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain, inflammation, and fever. It primarily achieves this by blocking the cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Pain relief usually begins within 30-60 minutes.
Excretion
Excreted rapidly in the urine, mainly as metabolites and their conjugates, with minimal unchanged drug.
Half life
Approximately 2 to 4 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by oxidation into two inactive metabolites, primarily via CYP2C9 and CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to ibuprofen or any component of the formulation, aspirin, or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding, or a history of recurrent ulceration/hemorrhage
- Severe heart failure, severe renal or hepatic impairment
- Third trimester of pregnancy (due to risk of premature closure of ductus arteriosus)
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
May reduce the hypotensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, drowsiness, dizziness, nystagmus, apnea, metabolic acidosis, and renal failure. Management involves gastric lavage, administration of activated charcoal, and symptomatic and supportive care.
Pregnancy & Lactation
Pregnancy: Avoid in the third trimester. In the first and second trimesters, use only if clearly needed and the potential benefit outweighs the potential risk. Lactation: Small amounts of ibuprofen are excreted in breast milk. Generally considered compatible with breastfeeding for short-term use, but consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to ibuprofen or any component of the formulation, aspirin, or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding, or a history of recurrent ulceration/hemorrhage
- Severe heart failure, severe renal or hepatic impairment
- Third trimester of pregnancy (due to risk of premature closure of ductus arteriosus)
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
May reduce the hypotensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, drowsiness, dizziness, nystagmus, apnea, metabolic acidosis, and renal failure. Management involves gastric lavage, administration of activated charcoal, and symptomatic and supportive care.
Pregnancy & Lactation
Pregnancy: Avoid in the third trimester. In the first and second trimesters, use only if clearly needed and the potential benefit outweighs the potential risk. Lactation: Small amounts of ibuprofen are excreted in breast milk. Generally considered compatible with breastfeeding for short-term use, but consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, depending on specific formulation and packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA for Bangladesh)
Patent Status
Off-patent (Generic)
WHO Essential Medicine
YesClinical Trials
Ibuprofen has undergone extensive clinical trials demonstrating its efficacy and safety for various indications. Ongoing research continues to explore its applications and long-term effects.
Lab Monitoring
- Monitor complete blood count (CBC) for anemia, especially during long-term therapy.
- Periodically assess renal function (serum creatinine, BUN) and liver function tests (ALT, AST) in patients on prolonged treatment or with underlying conditions.
- Monitor blood pressure regularly.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Assess cardiovascular and gastrointestinal risk factors before initiating and during NSAID therapy.
- Consider gastroprotective agents for patients at high risk of GI complications.
- Monitor renal function, liver enzymes, and blood pressure periodically, especially in elderly or patients with comorbidities.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose or duration of use without medical advice.
- Avoid alcohol while taking this medicine.
- Report any signs of stomach bleeding (e.g., black, tarry stools) or allergic reactions immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Neoflam may cause dizziness, drowsiness, or visual disturbances in some individuals. Patients should be cautioned about operating machinery or driving until they know how the medicine affects them.
Lifestyle Advice
- Avoid excessive alcohol consumption, as it can increase the risk of gastrointestinal bleeding.
- Maintain adequate hydration.
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