Neogest
Generic Name
Progesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neogest 2 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Neogest contains Progesterone, a naturally occurring steroid hormone. It is primarily used to supplement natural progesterone levels for various conditions, including menstrual disorders, infertility, and to support early pregnancy. It helps regulate the menstrual cycle, maintain the uterine lining, and facilitate implantation.
Uses & Indications
Dosage
Adults
Oral: 100-200 mg once or twice daily. Vaginal: 100-400 mg once or twice daily, depending on indication.
Elderly
Generally same as adults, with caution.
Renal_impairment
Use with caution; no specific dose adjustment data, but liver function is more critical.
How to Take
Oral capsules should be swallowed whole with water, preferably at bedtime. Vaginal suppositories/capsules should be inserted deep into the vagina.
Mechanism of Action
Progesterone acts on the endometrium, converting it from a proliferative to a secretory state, preparing the uterus for implantation. It also suppresses gonadotropin secretion, preventing ovulation. It relaxes smooth muscle, including the uterus, and helps maintain pregnancy.
Pharmacokinetics
Onset
Varies by route and indication; typically within hours.
Excretion
Primarily via urine as metabolites.
Half life
2-3 hours (oral), longer for sustained-release or vaginal forms.
Absorption
Well absorbed orally, but undergoes significant first-pass metabolism. Vaginal administration bypasses first-pass metabolism, leading to higher uterine concentrations.
Metabolism
Primarily in the liver to various metabolites, mainly pregnanediol.
Side Effects
Contraindications
- Known hypersensitivity to progesterone or any excipient
- Undiagnosed vaginal bleeding
- Severe liver dysfunction or disease
- Known or suspected hormone-dependent malignant tumours
- Thromboembolic disorders
Drug Interactions
CYP3A4 inducers (e.g., Rifampicin, Carbamazepine)
May decrease progesterone levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Grapefruit juice)
May increase progesterone levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, nausea, and fatigue. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Widely used to support early pregnancy and prevent threatened/habitual abortion. Generally considered safe during early pregnancy. Small amounts pass into breast milk; use with caution during lactation, consulting a doctor.
Side Effects
Contraindications
- Known hypersensitivity to progesterone or any excipient
- Undiagnosed vaginal bleeding
- Severe liver dysfunction or disease
- Known or suspected hormone-dependent malignant tumours
- Thromboembolic disorders
Drug Interactions
CYP3A4 inducers (e.g., Rifampicin, Carbamazepine)
May decrease progesterone levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Grapefruit juice)
May increase progesterone levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include drowsiness, dizziness, nausea, and fatigue. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Widely used to support early pregnancy and prevent threatened/habitual abortion. Generally considered safe during early pregnancy. Small amounts pass into breast milk; use with caution during lactation, consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical data supporting its use in luteal phase defect, threatened abortion, and HRT.
Lab Monitoring
- Liver function tests (periodically)
- Blood glucose (for diabetic patients)
Doctor Notes
- Ensure proper diagnosis before prescribing.
- Monitor patients for side effects and efficacy.
- Consider route of administration based on patient needs and tolerance.
Patient Guidelines
- Follow your doctor's instructions carefully.
- Report any unusual symptoms.
- Do not stop the medication suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet.
- Regular exercise may help manage symptoms associated with hormonal changes.
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Global Brand Names
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