Neoprox
Generic Name
Esomeprazole 40 mg Suspension
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neoprox 40 mg suspension | ৳ 98.37 | N/A |
Description
Overview of the medicine
Neoprox 40 mg Suspension contains Esomeprazole, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It is prescribed for conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. Zollinger-Ellison syndrome: Initial dose 40 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment required for elderly patients with normal renal function.
Renal_impairment
No dosage adjustment required for patients with renal impairment.
How to Take
For oral suspension, mix the powder with the recommended amount of water as per package instructions and take at least one hour before a meal. Do not chew or crush the granules if any.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically and irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This inhibition prevents the final step of acid production, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Approximately 80% is excreted as metabolites in the urine and the remainder in the feces.
Half life
Approximately 1.3 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% after a single 40 mg dose, increasing to 89% after repeated once-daily dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any other benzimidazole substituted proton pump inhibitors.
- Coadministration with Nelfinavir.
Drug Interactions
Digoxin
Increased digoxin absorption due to increased gastric pH.
Warfarin
Increased INR/prothrombin time, requiring monitoring.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
Possible increased methotrexate levels, especially with high doses.
Storage
Store unreconstituted powder below 30°C, protected from light and moisture. Reconstituted suspension should be stored at room temperature (15-30°C) and used within 28 days. Do not freeze.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, headache, and confusion. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Category C in pregnancy. Use only if potential benefit outweighs the potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). 28 days (reconstituted suspension) when stored at room temperature.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired for generic versions
Clinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety in GERD, erosive esophagitis, and other acid-related disorders.
Lab Monitoring
- No routine lab monitoring is generally required. In long-term therapy, monitor Vitamin B12 levels, magnesium levels, and bone mineral density (especially in elderly).
- Monitor INR in patients on concomitant Warfarin.
Doctor Notes
- Advise patients on appropriate administration technique for suspension.
- Counsel patients on potential long-term risks with PPI use.
- Consider dose adjustment or alternative therapy for patients with specific CYP2C19 genetic profiles if adverse effects are observed.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients. Advise caution when driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods like fatty, spicy, acidic foods, and caffeine.
- Elevate the head of your bed to reduce nighttime reflux.
- Quit smoking and reduce alcohol consumption.
- Maintain a healthy weight.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.