Neosol-DS
Generic Name
Dextrose 5% in 0.45% Sodium Chloride Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neosol ds 045 5 injection | ৳ 55.20 | N/A |
Description
Overview of the medicine
Neosol-DS 0.45-5 Injection is an intravenous solution containing 5% Dextrose and 0.45% Sodium Chloride, used for fluid, electrolyte, and caloric replacement. It helps restore circulating blood volume and maintain hydration.
Uses & Indications
Dosage
Adults
Individualized based on patient's age, weight, clinical condition, and fluid/electrolyte balance. Typically, 500-1000 mL administered intravenously over several hours, adjusted as needed by a healthcare professional.
Elderly
Lower doses and slower infusion rates may be required due to age-related physiological changes and potential renal impairment. Careful monitoring of fluid and electrolyte status is essential.
Renal_impairment
Use with extreme caution. Dosage and infusion rate must be carefully adjusted based on renal function and electrolyte levels to avoid fluid overload and electrolyte imbalances.
How to Take
Administered by slow intravenous infusion using sterile equipment. The rate of administration should be determined by a healthcare professional based on the patient's clinical needs.
Mechanism of Action
Provides water, electrolytes (sodium and chloride), and calories in the form of dextrose. Dextrose is metabolized to carbon dioxide and water, providing energy. Sodium is the principal cation of extracellular fluid, and chloride is the principal anion. These components help maintain osmotic pressure and acid-base balance.
Pharmacokinetics
Onset
Immediate
Excretion
Water and metabolic byproducts (CO2) are excreted via lungs and kidneys. Excess sodium and chloride are primarily excreted by the kidneys.
Half life
Not directly applicable for electrolytes and dextrose, as they are metabolized and excreted continuously to maintain homeostasis. Components are rapidly distributed.
Absorption
Administered intravenously, hence 100% bioavailable immediately.
Metabolism
Dextrose is metabolized via glycolysis and the Krebs cycle to produce energy. Sodium and chloride ions are essential for various physiological processes and are regulated by renal mechanisms.
Side Effects
Contraindications
- Known hypersensitivity to dextrose or sodium chloride.
- Severe renal impairment with anuria.
- Fluid overload (hypervolemia) or edema.
- Hyperglycemia, especially in uncontrolled diabetes.
- Hypernatremia.
- Severe congestive heart failure.
Drug Interactions
Insulin
May be required to manage hyperglycemia when infusing dextrose solutions, especially in diabetic patients.
Corticosteroids
May increase sodium retention and fluid overload risk.
Drugs that alter renal sodium excretion (e.g., diuretics)
May affect electrolyte balance and require dose adjustments.
Storage
Store at room temperature (20°C to 25°C), protected from freezing and excessive heat. Do not store in direct sunlight. Avoid storing above 30°C.
Overdose
Symptoms include fluid overload (peripheral edema, pulmonary congestion, increased blood pressure), electrolyte disturbances (hypernatremia, hyperglycemia, hypokalemia), and acid-base imbalance. Treatment involves discontinuing the infusion, administering diuretics if needed, and correcting electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe when clinically indicated and administered appropriately. Fluid and electrolyte balance should be carefully monitored in pregnant and lactating women, as imbalances can affect both mother and fetus/infant.
Side Effects
Contraindications
- Known hypersensitivity to dextrose or sodium chloride.
- Severe renal impairment with anuria.
- Fluid overload (hypervolemia) or edema.
- Hyperglycemia, especially in uncontrolled diabetes.
- Hypernatremia.
- Severe congestive heart failure.
Drug Interactions
Insulin
May be required to manage hyperglycemia when infusing dextrose solutions, especially in diabetic patients.
Corticosteroids
May increase sodium retention and fluid overload risk.
Drugs that alter renal sodium excretion (e.g., diuretics)
May affect electrolyte balance and require dose adjustments.
Storage
Store at room temperature (20°C to 25°C), protected from freezing and excessive heat. Do not store in direct sunlight. Avoid storing above 30°C.
Overdose
Symptoms include fluid overload (peripheral edema, pulmonary congestion, increased blood pressure), electrolyte disturbances (hypernatremia, hyperglycemia, hypokalemia), and acid-base imbalance. Treatment involves discontinuing the infusion, administering diuretics if needed, and correcting electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe when clinically indicated and administered appropriately. Fluid and electrolyte balance should be carefully monitored in pregnant and lactating women, as imbalances can affect both mother and fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date. Refer to the product label for the exact expiry date.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
As a well-established and essential solution, extensive modern clinical trials for its basic use are not common. Its efficacy and safety are well-documented over decades of clinical use and regulatory approvals worldwide.
Lab Monitoring
- Serum electrolytes (sodium, potassium, chloride, bicarbonate)
- Blood glucose levels
- Renal function tests (BUN, creatinine)
- Fluid balance (intake and output)
- Vital signs (blood pressure, heart rate)
Doctor Notes
- Strictly monitor fluid intake and output, serum electrolytes, and blood glucose regularly during administration.
- Administer cautiously in patients with cardiac or renal impairment, severe dehydration, or uncontrolled diabetes.
- Do not administer if the solution is discolored, turbid, or contains particulate matter, or if the container is damaged.
- Hypokalemia can occur during dextrose infusion, requiring potassium supplementation.
Patient Guidelines
- This medication is administered by a healthcare professional in a clinical setting.
- Report any discomfort, pain, swelling, or redness at the injection site immediately.
- Inform your doctor about any pre-existing medical conditions, especially heart or kidney problems, and all other medications you are taking.
Missed Dose Advice
This medication is administered in a controlled clinical setting, and dosing is managed by a healthcare provider. A missed dose is not typically applicable in this context.
Driving Precautions
Not applicable as this medication is typically administered in a hospital setting to patients who are usually not in a condition to drive.
Lifestyle Advice
- While this specific IV solution does not require specific lifestyle changes, adherence to dietary and fluid restrictions related to the underlying medical condition requiring the infusion is crucial.
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