Nepafix TS
Generic Name
Tobramycin + Dexamethasone
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nepafix ts 03 suspension | ৳ 225.00 | N/A |
Description
Overview of the medicine
Nepafix TS is an ophthalmic solution that combines an aminoglycoside antibiotic (Tobramycin) and a corticosteroid (Dexamethasone) to treat bacterial eye infections and associated inflammation. It is effective against a broad range of susceptible ocular bacterial pathogens.
Uses & Indications
Dosage
Adults
Instill 1-2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours. For severe disease, instill 1-2 drops every 2 hours for the first 24 to 48 hours, then reduce frequency as the infection subsides.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment due to minimal systemic absorption.
How to Take
Wash hands thoroughly before use. Tilt your head back, pull down the lower eyelid to create a small pouch, and instill the prescribed number of drops. Avoid touching the dropper tip to the eye or any other surface to prevent contamination. Close your eye gently for a few minutes.
Mechanism of Action
Tobramycin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to bacterial cell death. Dexamethasone is a potent synthetic corticosteroid that suppresses inflammatory responses by inhibiting the release of inflammatory mediators and reducing capillary permeability.
Pharmacokinetics
Onset
Rapid relief of symptoms usually begins within hours to a few days, depending on the severity of the condition.
Excretion
Primarily local elimination from the ocular surface. Any systemically absorbed portion is rapidly excreted, mainly via kidneys.
Half life
Systemic half-life is not clinically relevant for topical ocular administration due to minimal absorption.
Absorption
Minimal systemic absorption occurs after topical ocular administration. Most of the active ingredients remain localized in the ocular tissues.
Metabolism
Minimal systemic metabolism. Dexamethasone undergoes hepatic metabolism, but systemic levels are negligible with ocular drops.
Side Effects
Contraindications
- Epithelial herpes simplex keratitis (dendritic keratitis).
- Vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva.
- Mycobacterial infection of the eye.
- Fungal diseases of ocular structures.
- Hypersensitivity to any component of the medication.
Drug Interactions
Other topical ophthalmic medications
If more than one topical ophthalmic product is being used, they should be administered at least 5 minutes apart.
Other topical ophthalmic corticosteroids
Concurrent use with other steroid eye drops may increase the risk of elevated intraocular pressure.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Accidental overdose with topical ocular administration is unlikely to cause systemic toxicity due to limited absorption. If swallowed, gastric lavage may be considered in cases of large ingestion, though it's an unlikely scenario.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Dexamethasone may pass into breast milk; use with caution in lactating mothers. Consult a doctor before use.
Side Effects
Contraindications
- Epithelial herpes simplex keratitis (dendritic keratitis).
- Vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva.
- Mycobacterial infection of the eye.
- Fungal diseases of ocular structures.
- Hypersensitivity to any component of the medication.
Drug Interactions
Other topical ophthalmic medications
If more than one topical ophthalmic product is being used, they should be administered at least 5 minutes apart.
Other topical ophthalmic corticosteroids
Concurrent use with other steroid eye drops may increase the risk of elevated intraocular pressure.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Accidental overdose with topical ocular administration is unlikely to cause systemic toxicity due to limited absorption. If swallowed, gastric lavage may be considered in cases of large ingestion, though it's an unlikely scenario.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Dexamethasone may pass into breast milk; use with caution in lactating mothers. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened); 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved (e.g., by DGDA)
Patent Status
Off-patent (for the combination)
Clinical Trials
Numerous clinical trials have supported the efficacy and safety of Tobramycin and Dexamethasone combination for ocular infections and inflammation. Specific trials for Nepafix TS would relate to its bioequivalence or local market approval.
Doctor Notes
- Counsel patients on proper administration technique to minimize contamination and ensure effective delivery.
- Monitor intraocular pressure in patients receiving prolonged therapy, especially those with a history of glaucoma or ocular hypertension.
- Not indicated for unsupervised long-term use. Emphasize adherence to prescribed duration of treatment.
Patient Guidelines
- Do not wear contact lenses during treatment with Nepafix TS.
- Do not use this medication for longer than prescribed by your doctor to avoid potential side effects like increased eye pressure or cataract formation.
- Consult your doctor if symptoms worsen or do not improve after a few days of treatment.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Nepafix TS may cause temporary blurring of vision after administration. Patients should be advised not to drive or operate machinery until their vision clears.
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