Nepofer
Generic Name
Ferric Carboxymaltose
Manufacturer
XYZ Pharmaceuticals
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nepofer 272 mg injection | ৳ 500.00 | N/A |
Description
Overview of the medicine
Nepofer 272 mg Injection contains Ferric Carboxymaltose, an iron carbohydrate complex designed for intravenous administration. It is used to treat iron deficiency anemia when oral iron preparations are ineffective or cannot be used, or when there is a clinical need for rapid iron repletion.
Uses & Indications
Dosage
Adults
Individualized based on total iron deficit. Typically 1000 mg of iron given as a single infusion or split into two doses (e.g., 500 mg each) administered at least 7 days apart. Maximum single dose: 1000 mg. For Nepofer 272 mg, the physician will determine the number of vials needed.
Elderly
No specific dose adjustment required, but caution is advised in elderly patients with pre-existing cardiovascular conditions.
Renal_impairment
No specific dose adjustment needed for patients with non-dialysis dependent chronic kidney disease. Use with caution in hemodialysis patients.
How to Take
Intravenous infusion. Administer slowly over at least 15 minutes for doses up to 1000 mg. Administer in a setting where resuscitation facilities are available in case of anaphylactic reactions.
Mechanism of Action
Ferric Carboxymaltose is a colloidal iron hydroxide in complex with a carbohydrate polymer. After intravenous administration, the iron carbohydrate complex is taken up by the reticuloendothelial system (RES), primarily in the liver, spleen, and bone marrow. Here, iron is released from the complex and incorporated into transferrin, ferritin, and hemoglobin.
Pharmacokinetics
Onset
Increase in hemoglobin levels typically seen within 1-2 weeks.
Excretion
Small amounts of non-metabolized iron may be excreted via urine and feces. Primarily incorporated into physiological pathways.
Half life
Circulating half-life for elemental iron is approximately 7-12 hours.
Absorption
Administered intravenously, hence 100% bioavailability. Iron released from the complex into the reticuloendothelial system.
Metabolism
Iron is separated from the carbohydrate complex and transported to the iron pool where it's incorporated into hemoglobin, ferritin, or transferrin.
Side Effects
Contraindications
- Hypersensitivity to Ferric Carboxymaltose or any of its excipients.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia).
- Iron overload or disturbances in iron utilization.
- First trimester of pregnancy.
Drug Interactions
Oral iron preparations
Concomitant administration with oral iron preparations may reduce the absorption of oral iron. Oral iron should not be started until at least 5 days after the last Ferric Carboxymaltose injection.
Storage
Store below 30°C. Do not freeze. Protect from light.
Overdose
Symptoms may include acute iron overload leading to hemosiderosis. Treatment involves supportive measures, monitoring of iron parameters, and potentially chelation therapy if severe.
Pregnancy & Lactation
Pregnancy: Use in the second and third trimesters only if the potential benefit outweighs the potential risk to the mother and fetus. Not recommended in the first trimester. Lactation: Limited data suggest minimal transfer into breast milk. Use with caution.
Side Effects
Contraindications
- Hypersensitivity to Ferric Carboxymaltose or any of its excipients.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia).
- Iron overload or disturbances in iron utilization.
- First trimester of pregnancy.
Drug Interactions
Oral iron preparations
Concomitant administration with oral iron preparations may reduce the absorption of oral iron. Oral iron should not be started until at least 5 days after the last Ferric Carboxymaltose injection.
Storage
Store below 30°C. Do not freeze. Protect from light.
Overdose
Symptoms may include acute iron overload leading to hemosiderosis. Treatment involves supportive measures, monitoring of iron parameters, and potentially chelation therapy if severe.
Pregnancy & Lactation
Pregnancy: Use in the second and third trimesters only if the potential benefit outweighs the potential risk to the mother and fetus. Not recommended in the first trimester. Lactation: Limited data suggest minimal transfer into breast milk. Use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months when stored as recommended.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved
Patent Status
Patent Expired for generic, brand may have specific patents
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various patient populations with iron deficiency anemia, including those with chronic kidney disease and women in the postpartum period.
Lab Monitoring
- Hemoglobin (Hb) levels
- Serum ferritin
- Transferrin saturation (TSAT)
- Serum phosphate (especially in patients at risk of hypophosphatemia)
Doctor Notes
- Monitor for signs and symptoms of hypersensitivity reactions during and after administration.
- Regularly assess iron parameters (Hb, ferritin, TSAT) to guide treatment and prevent iron overload.
Patient Guidelines
- Report any allergic reactions, especially difficulty breathing, rash, or swelling, immediately during or after infusion.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Follow up with your doctor for blood tests to monitor iron levels and hemoglobin.
Missed Dose Advice
Contact your doctor or nurse to reschedule a missed dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in iron (e.g., red meat, leafy greens, fortified cereals) as advised by your doctor.
- Stay hydrated.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.