Nerupa
Generic Name
nerupa-10-mg-tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerupa 10 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Nerupa 10 mg Tablet contains Aripiprazole, an atypical antipsychotic medication used to treat certain mental or mood disorders such as schizophrenia, bipolar disorder, and depression. It helps to restore the balance of certain natural substances in the brain (neurotransmitters) to improve mood, thinking, and behavior.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 10-15 mg once daily, target dose 10-15 mg once daily. Max 30 mg/day. Bipolar I Disorder: Initially 15 mg once daily, target dose 15 mg once daily. Max 30 mg/day. Adjunctive Depression: Initially 2-5 mg once daily, target dose 5-15 mg once daily.
Elderly
No specific dose adjustment is generally recommended based on age alone, but caution is advised. Start with lower doses and titrate gradually.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Aripiprazole is thought to act as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This unique mechanism is believed to contribute to its efficacy in stabilizing dopamine and serotonin systems.
Pharmacokinetics
Onset
Clinical effects may take several days to weeks to fully manifest.
Excretion
Excreted primarily through feces (55%) and urine (25%).
Half life
Mean terminal elimination half-life is approximately 75 hours for aripiprazole and 94 hours for its active metabolite, dehydro-aripiprazole.
Absorption
Well absorbed after oral administration, peak plasma concentrations typically occur within 3-5 hours. Absolute oral bioavailability is approximately 87%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes. Dehydro-aripiprazole is the only active metabolite.
Side Effects
Contraindications
- •Known hypersensitivity to aripiprazole or any component of the formulation.
- •History of neuroleptic malignant syndrome (NMS).
Drug Interactions
Antihypertensive agents
May enhance hypotensive effects.
CYP2D6 inhibitors (e.g., quinidine, fluoxetine)
May increase aripiprazole levels, requiring dose reduction.
CYP3A4 inducers (e.g., carbamazepine, rifampicin)
May decrease aripiprazole levels, requiring dose increase.
CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
May increase aripiprazole levels, requiring dose reduction.
Central nervous system (CNS) depressants (e.g., alcohol, benzodiazepines)
May enhance CNS depressant effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tremor, and tachycardia. Management involves supportive care, maintaining airway, ventilation, and oxygenation. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired (generic versions available)
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
