Nesudil
Generic Name
Naphazoline Hydrochloride, Pheniramine Maleate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nesudil 002 eye drop | ৳ 600.00 | N/A |
Description
Overview of the medicine
Nesudil eye drop contains Naphazoline Hydrochloride, a sympathomimetic decongestant, and Pheniramine Maleate, an antihistamine. It is used to relieve redness, itching, and congestion associated with allergic conjunctivitis and minor eye irritations.
Uses & Indications
Dosage
Adults
1-2 drops in the affected eye(s) up to 4 times a day, or as directed by a physician.
Elderly
No specific dosage adjustment needed, use as adult dosage.
Renal_impairment
Not applicable for ophthalmic use with minimal systemic absorption.
How to Take
For ophthalmic use only. Tilt head back, pull down lower eyelid to form a pouch, apply drops, and close eye gently. Do not touch the dropper tip to the eye or any other surface.
Mechanism of Action
Naphazoline acts as a vasoconstrictor, reducing redness and swelling by constricting conjunctival blood vessels. Pheniramine is an H1-receptor antagonist, blocking histamine action to relieve itching and watery eyes.
Pharmacokinetics
Onset
Within 5-10 minutes.
Excretion
Primarily local action, minimal excretion through systemic routes.
Half life
Not well-characterized for ophthalmic use due to minimal systemic absorption.
Absorption
Minimal systemic absorption after ocular administration.
Metabolism
Not significantly metabolized systemically.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Narrow-angle glaucoma.
- Serious cardiovascular disease.
Drug Interactions
MAO Inhibitors
Concurrent use with MAO inhibitors may lead to hypertensive crisis due to naphazoline.
Tricyclic Antidepressants
Potentiates the pressor effect of naphazoline.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight. Do not freeze.
Overdose
Systemic overdose is unlikely with proper ophthalmic use. Symptoms of systemic overdose (if ingested) may include central nervous system depression, hypotension, coma, and respiratory depression.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Narrow-angle glaucoma.
- Serious cardiovascular disease.
Drug Interactions
MAO Inhibitors
Concurrent use with MAO inhibitors may lead to hypertensive crisis due to naphazoline.
Tricyclic Antidepressants
Potentiates the pressor effect of naphazoline.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight. Do not freeze.
Overdose
Systemic overdose is unlikely with proper ophthalmic use. Symptoms of systemic overdose (if ingested) may include central nervous system depression, hypotension, coma, and respiratory depression.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months (unopened). Discard 28 days after opening.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic
Clinical Trials
Well-established combination, further large-scale clinical trials specifically for this formulation are rare.
Lab Monitoring
- Not typically required for ophthalmic use.
Doctor Notes
- Advise patients against prolonged use to prevent rebound effects.
- Check for history of glaucoma or cardiovascular issues before prescribing.
- Remind patients about proper sterile administration techniques.
Patient Guidelines
- Do not use for more than 3-4 consecutive days to avoid rebound congestion.
- Remove contact lenses before use and wait at least 15 minutes before reinserting.
- If eye pain, vision changes, or continued redness/irritation occurs, discontinue use and consult a doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision. Avoid driving or operating machinery until vision is clear.
Lifestyle Advice
- Avoid rubbing eyes.
- Maintain good eye hygiene.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.