Neural
Generic Name
Methylcobalamin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neural 500 mcg tablet | ৳ 4.25 | ৳ 42.50 |
Description
Overview of the medicine
Neural 500 mcg tablet contains Methylcobalamin, a coenzyme form of Vitamin B12, essential for nervous system function, blood formation, and DNA synthesis. It is used to treat vitamin B12 deficiency and associated neurological conditions.
Uses & Indications
Dosage
Adults
Typically 500 mcg to 1500 mcg per day, orally, once daily. Dosage may vary based on deficiency severity and medical condition.
Elderly
Similar to adult dosage, but caution with concomitant medications and renal function.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment. For severe impairment, consult a physician.
How to Take
Can be taken with or without food. Some formulations are sublingual and should be dissolved under the tongue.
Mechanism of Action
Methylcobalamin acts as a coenzyme in two crucial metabolic pathways: the conversion of homocysteine to methionine (via methionine synthase) and the isomerization of methylmalonyl-CoA to succinyl-CoA (via methylmalonyl-CoA mutase). These processes are vital for nerve health, red blood cell production, and overall cellular metabolism.
Pharmacokinetics
Onset
Therapeutic effects may be observed within weeks to months, depending on the severity of deficiency and route of administration.
Excretion
Primarily renal excretion of unmetabolized and metabolized forms. Enterohepatic recirculation also occurs.
Half life
Approximately 6 days in plasma; however, stores in the liver can last for years.
Absorption
Well absorbed orally, especially with intrinsic factor. Sublingual absorption is also good, bypassing intrinsic factor dependency.
Metabolism
Primarily converted to other active forms (adenosylcobalamin) and stored in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Methylcobalamin or any component of the formulation
- •Leber's disease (due to risk of optic nerve damage)
Drug Interactions
Metformin
Long-term use may decrease Vitamin B12 absorption.
Chloramphenicol
May reduce the hematologic response to Vitamin B12.
H2 Receptor Blockers (e.g., Ranitidine, Cimetidine)
May reduce absorption of oral Vitamin B12.
Proton Pump Inhibitors (e.g., Omeprazole, Lansoprazole)
May reduce absorption of oral Vitamin B12 with long-term use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Methylcobalamin is generally considered non-toxic even at high doses due to its water-soluble nature and rapid excretion. No specific antidote. Symptomatic and supportive treatment if required.
Pregnancy & Lactation
Considered safe during pregnancy and lactation at recommended doses, as Vitamin B12 is essential for fetal development and is excreted in breast milk. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, drug stores, online health stores
Approval Status
Approved by drug regulatory authorities
Patent Status
Generic (Patent expired for Methylcobalamin)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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