Neusangel
Generic Name
Esomeprazole 40 mg capsule
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neusangel 40 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Neusangel 40 mg Capsule contains Esomeprazole, a proton pump inhibitor (PPI) used to reduce stomach acid production. It is prescribed for the treatment of various acid-related conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and conditions involving excessive stomach acid.
Uses & Indications
Dosage
Adults
For GERD: 40 mg once daily for 4-8 weeks. For H. pylori eradication: 40 mg once daily in combination with antibiotics. For Zollinger-Ellison Syndrome: Initial dose of 40 mg twice daily, adjusted as needed.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole, at least one hour before a meal, usually in the morning. Do not chew or crush the capsule.
Mechanism of Action
Esomeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) in the gastric parietal cells. This action blocks the final step of gastric acid secretion, significantly reducing stomach acid levels.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 1 hour.
Excretion
Excreted primarily as metabolites in the urine (approximately 80%) and feces (approximately 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability increases with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (CYP2C19 and CYP3A4 enzymes).
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Diazepam
Increased plasma levels of diazepam due to inhibition of CYP2C19.
Warfarin
Increased risk of bleeding due to inhibition of CYP2C19.
Clopidogrel
Reduced effectiveness of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Possible increase in methotrexate levels, especially with high doses.
Storage
Store in a cool, dry place below 25°C, away from direct light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Esomeprazole is likely excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Diazepam
Increased plasma levels of diazepam due to inhibition of CYP2C19.
Warfarin
Increased risk of bleeding due to inhibition of CYP2C19.
Clopidogrel
Reduced effectiveness of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Possible increase in methotrexate levels, especially with high doses.
Storage
Store in a cool, dry place below 25°C, away from direct light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Esomeprazole is likely excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Studies have shown superior efficacy compared to some other PPIs in certain conditions.
Lab Monitoring
- No specific routine lab monitoring is required. However, long-term use may necessitate monitoring of vitamin B12 levels.
Doctor Notes
- Consider lowest effective dose and shortest duration for treatment.
- Evaluate for underlying conditions before initiating PPI therapy.
- Monitor for potential long-term adverse effects, especially in elderly patients.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Neusangel generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid spicy and fatty foods.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Quit smoking and reduce alcohol intake.
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