Neuvit Plus
Generic Name
Thiamine Mononitrate 100 mg, Pyridoxine Hydrochloride 200 mg, Cyanocobalamin 200 mcg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neuvit plus 100 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Neuvit Plus 100 mg Tablet is a combination of essential B vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) crucial for nerve health, metabolism, and red blood cell formation. It is used to treat and prevent deficiencies of these vitamins.
Uses & Indications
Dosage
Adults
Typically 1-3 tablets daily, or as directed by a physician.
Elderly
Same as adult dosage, no specific adjustment usually required unless significant renal impairment.
Renal_impairment
Use with caution in severe renal impairment; dose adjustment may be necessary for B6.
How to Take
To be taken orally, with or without food. Can be taken with food to minimize gastrointestinal upset.
Mechanism of Action
Thiamine (B1) acts as a coenzyme in carbohydrate metabolism. Pyridoxine (B6) is essential for amino acid metabolism, neurotransmitter synthesis, and hemoglobin formation. Cyanocobalamin (B12) is vital for DNA synthesis, red blood cell production, and neurological function.
Pharmacokinetics
Onset
Symptoms may improve within days to weeks depending on severity of deficiency.
Excretion
Excreted primarily via urine.
Half life
Thiamine: 9-18 days; Pyridoxine: 15-20 days; Cyanocobalamin: variable, generally long.
Absorption
Well absorbed orally, especially Thiamine and Pyridoxine. Cyanocobalamin absorption requires intrinsic factor.
Metabolism
Metabolized in the liver to active forms.
Side Effects
Contraindications
- Hypersensitivity to any of the active ingredients or excipients
- Leber's disease (due to Cyanocobalamin)
Drug Interactions
Levodopa
Pyridoxine (B6) can decrease the effectiveness of Levodopa in Parkinson's disease (this interaction is significant only with high doses of B6 without a DOPA decarboxylase inhibitor).
Phenobarbital, Phenytoin
Pyridoxine can decrease serum concentrations of these antiepileptic drugs.
Colchicine, Neomycin, Aminosalicylic acid
May impair absorption of Cyanocobalamin (B12).
Storage
Store in a cool, dry place below 30°C, away from light and moisture.
Overdose
Overdose is rare due to water-soluble nature of vitamins. Excessive Pyridoxine (B6) can cause peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased nutritional demands, but consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to any of the active ingredients or excipients
- Leber's disease (due to Cyanocobalamin)
Drug Interactions
Levodopa
Pyridoxine (B6) can decrease the effectiveness of Levodopa in Parkinson's disease (this interaction is significant only with high doses of B6 without a DOPA decarboxylase inhibitor).
Phenobarbital, Phenytoin
Pyridoxine can decrease serum concentrations of these antiepileptic drugs.
Colchicine, Neomycin, Aminosalicylic acid
May impair absorption of Cyanocobalamin (B12).
Storage
Store in a cool, dry place below 30°C, away from light and moisture.
Overdose
Overdose is rare due to water-soluble nature of vitamins. Excessive Pyridoxine (B6) can cause peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased nutritional demands, but consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by local drug authorities (e.g., DGDA)
Patent Status
Generic/Off-patent
Clinical Trials
As a widely used vitamin combination, extensive clinical trials for efficacy and safety are generally not required for new formulations unless novel delivery or indications.
Lab Monitoring
- Serum B12 levels (if deficiency suspected)
- Pyridoxine levels (if high doses or toxicity suspected)
Doctor Notes
- Essential for nerve function and metabolic processes.
- Monitor for signs of peripheral neuropathy with prolonged high dose B6 therapy.
- Advise patients on dietary sources of B vitamins.
Patient Guidelines
- Take as directed by your healthcare provider.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally no specific precautions needed as it does not typically cause drowsiness or impair driving ability.
Lifestyle Advice
- Maintain a balanced diet.
- Avoid excessive alcohol intake.
- If treating neuropathy, manage underlying conditions like diabetes.
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Global Brand Names
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