nevan-ts
Generic Name
Tacrolimus Ophthalmic Suspension
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nevan ts 03 suspension | ৳ 250.00 | N/A |
Description
Overview of the medicine
Tacrolimus 0.03% ophthalmic suspension is an immunosuppressant eye drop used to reduce inflammation in severe allergic conjunctivitis or dry eye disease (in some cases).
Uses & Indications
Dosage
Adults
1 drop in each affected eye twice daily.
Elderly
Same as adults.
Renal_impairment
Generally no dose adjustment required for ophthalmic use due to minimal systemic absorption.
How to Take
For ophthalmic use only. Shake well before use. Apply to the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface.
Mechanism of Action
It inhibits calcineurin, thereby preventing T-lymphocyte activation and reducing inflammation.
Pharmacokinetics
Onset
Days to weeks for full effect.
Excretion
Mainly fecal, if systemically absorbed, but systemic absorption from ophthalmic use is negligible.
Half life
Systemic half-life is long, but ocular pharmacokinetics are localized.
Absorption
Minimal systemic absorption after ophthalmic administration.
Metabolism
Primarily hepatic (CYP3A4) if systemically absorbed, but systemic absorption from ophthalmic use is negligible.
Side Effects
Contraindications
- Hypersensitivity to tacrolimus or any component of the suspension
- Active ocular infections
Drug Interactions
Other Eye Drops
Wait at least 5 minutes before applying other eye drops.
Systemic CYP3A4 inhibitors
Although systemic absorption is minimal, avoid concomitant use with systemic CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) if possible, or monitor closely.
Storage
Store below 25°C, protected from light and in a dry place. Do not refrigerate.
Overdose
Overdose is unlikely with ophthalmic use. In case of excessive use, rinse the eye with water.
Pregnancy & Lactation
Use with caution; consult a doctor before use during pregnancy or lactation. Should only be used if clearly necessary after assessing risks and benefits.
Side Effects
Contraindications
- Hypersensitivity to tacrolimus or any component of the suspension
- Active ocular infections
Drug Interactions
Other Eye Drops
Wait at least 5 minutes before applying other eye drops.
Systemic CYP3A4 inhibitors
Although systemic absorption is minimal, avoid concomitant use with systemic CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) if possible, or monitor closely.
Storage
Store below 25°C, protected from light and in a dry place. Do not refrigerate.
Overdose
Overdose is unlikely with ophthalmic use. In case of excessive use, rinse the eye with water.
Pregnancy & Lactation
Use with caution; consult a doctor before use during pregnancy or lactation. Should only be used if clearly necessary after assessing risks and benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As per official information (typically 1-2 years unopened, 1 month after opening).
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic (Formulation might be patented)
Clinical Trials
Various studies have evaluated its efficacy and safety in allergic conjunctivitis, dry eye, and other ocular inflammatory conditions.
Lab Monitoring
- No routine lab monitoring is typically required for ophthalmic tacrolimus due to minimal systemic absorption.
Doctor Notes
- Educate patients thoroughly about proper administration and the importance of compliance.
- Advise regular follow-up, especially for signs of ocular infection or other adverse effects.
Patient Guidelines
- Shake well before use.
- Do not touch the dropper tip to the eye or any other surface.
- Remove contact lenses before use and wait at least 15 minutes before reinserting.
- Inform your doctor of any worsening or new symptoms.
Missed Dose Advice
If a dose is missed, use it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and follow your regular schedule.
Driving Precautions
May cause temporary blurred vision; avoid driving or operating heavy machinery until vision clears.
Lifestyle Advice
- Avoid eye rubbing.
- Maintain good eye hygiene.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.