Newcip
Generic Name
Ciprofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| newcip 500 mg tablet | ৳ 14.00 | N/A |
Description
Overview of the medicine
Newcip 500 mg Tablet contains Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and gastrointestinal infections.
Uses & Indications
Dosage
Adults
Typically 250-750 mg twice daily, depending on the infection type and severity. Duration of treatment varies.
Elderly
No specific dosage adjustment is required based on age, but renal function should be considered.
Renal_impairment
Dosage adjustment is necessary for patients with severe renal impairment (creatinine clearance < 30 mL/min). A reduced dose or extended dosing interval may be required.
How to Take
Swallow the tablet whole with a glass of water. It can be taken with or without food, but avoid taking it with dairy products (milk, yogurt) or calcium-fortified juices as these can reduce absorption. Take at least 2 hours before or 6 hours after antacids containing magnesium, aluminum, calcium, or iron supplements.
Mechanism of Action
Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Within 0.5-2 hours of administration.
Excretion
Primarily excreted unchanged by the kidneys (50-70%) and to a lesser extent via the feces.
Half life
Approximately 3-5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; absolute bioavailability is approximately 70-80%. Peak plasma concentrations are reached 0.5-2 hours after oral administration.
Metabolism
Undergoes limited hepatic metabolism (10-20%) to several less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- Concomitant administration with tizanidine.
- History of tendinitis or tendon rupture associated with quinolone use.
- Children and adolescents (under 18 years), except for specific severe infections where benefits outweigh risks.
Drug Interactions
NSAIDs
Potential for increased CNS stimulation and convulsions.
Warfarin
Enhanced anticoagulant effects, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased plasma concentrations of tizanidine.
Cyclosporine
Increased serum creatinine and potential for nephrotoxicity.
Theophylline
Increased plasma levels of theophylline, potentially leading to toxicity.
Antacids, Iron/Zinc Supplements, Sucralfate, Didanosine
Reduced ciprofloxacin absorption. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and supportive care are recommended. Hydration should be maintained. Hemodialysis or peritoneal dialysis is not effective in removing ciprofloxacin.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk, and after consulting a doctor. Ciprofloxacin is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones.
- Concomitant administration with tizanidine.
- History of tendinitis or tendon rupture associated with quinolone use.
- Children and adolescents (under 18 years), except for specific severe infections where benefits outweigh risks.
Drug Interactions
NSAIDs
Potential for increased CNS stimulation and convulsions.
Warfarin
Enhanced anticoagulant effects, requiring INR monitoring.
Tizanidine
Concomitant use is contraindicated due to increased plasma concentrations of tizanidine.
Cyclosporine
Increased serum creatinine and potential for nephrotoxicity.
Theophylline
Increased plasma levels of theophylline, potentially leading to toxicity.
Antacids, Iron/Zinc Supplements, Sucralfate, Didanosine
Reduced ciprofloxacin absorption. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and supportive care are recommended. Hydration should be maintained. Hemodialysis or peritoneal dialysis is not effective in removing ciprofloxacin.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk, and after consulting a doctor. Ciprofloxacin is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function tests (especially in patients with pre-existing renal impairment).
- Liver function tests (in patients with hepatic impairment or during prolonged therapy).
- INR (for patients on warfarin therapy).
- Blood glucose (in diabetic patients).
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients.
- Counsel patients on potential severe adverse reactions and the need for immediate discontinuation if symptoms occur.
- Consider drug interactions, particularly with tizanidine, theophylline, and warfarin.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Avoid excessive exposure to sunlight or artificial UV light while taking this medicine.
- Stay well-hydrated by drinking plenty of fluids.
- Do not take with dairy products or calcium-fortified juices.
- Report any unusual pain, especially in tendons, numbness, tingling, or weakness immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ciprofloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should be cautioned against operating machinery or driving until they are reasonably certain that ciprofloxacin therapy does not affect them adversely.
Lifestyle Advice
- Ensure adequate fluid intake to prevent crystalluria.
- Protect skin from sun exposure (wear protective clothing, use sunscreen).
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