Ngcef-DS
Generic Name
Cefixime 200 mg Suspension
Manufacturer
Unimed Unihealth Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ngcef ds 200 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Ngcef-DS 200 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Adults and children over 10 years: 200 mg twice daily for 7-14 days. For certain infections, a single dose of 400 mg may be used.
Elderly
No dosage adjustment needed unless severe renal impairment is present.
Renal_impairment
Creatinine clearance 21-60 mL/min: 75% of standard dose. Creatinine clearance <20 mL/min: 50% of standard dose.
How to Take
Reconstitute the dry powder with boiled and cooled water as directed by the physician. Shake well before each use. Can be taken with or without food.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours post-dose.
Excretion
Primarily excreted unchanged in the urine (approximately 50-60%) and also through bile.
Half life
Average plasma half-life is 3 to 4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized. A small percentage is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time and international normalized ratio (INR), leading to increased bleeding risk.
Probenecid
May increase cefixime plasma concentrations by decreasing renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime administration.
Storage
Store dry powder below 30°C in a dry place, away from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C).
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in human milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time and international normalized ratio (INR), leading to increased bleeding risk.
Probenecid
May increase cefixime plasma concentrations by decreasing renal excretion.
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime administration.
Storage
Store dry powder below 30°C in a dry place, away from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C).
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in human milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2-3 years. Reconstituted suspension: 7-14 days when refrigerated.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Cefixime for indicated bacterial infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (rarely for prolonged therapy)
- Liver function tests (rarely)
Doctor Notes
- Advise patients to complete the full antibiotic course.
- Counsel on potential gastrointestinal side effects like diarrhea.
- Check for penicillin allergy history before prescribing.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Shake the suspension well before each use.
- Measure the dose accurately using the provided measuring device.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally does not affect the ability to drive or operate machinery. However, dizziness has been reported rarely, so caution is advised.
Lifestyle Advice
- Maintain good hydration.
- Avoid self-medication with antibiotics.
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