Nirvoy
Generic Name
Aripiprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nirvoy 15 mg tablet | ৳ 80.00 | N/A |
Description
Overview of the medicine
Aripiprazole is an atypical antipsychotic medication used to treat conditions such as schizophrenia, bipolar I disorder (manic and mixed episodes), major depressive disorder (as an adjunct), and irritability associated with autistic disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 10-15 mg once daily, target 15 mg/day. Bipolar mania: Initial 15 mg once daily. Adjunctive Major Depressive Disorder: Initial 2-5 mg once daily, target 10-15 mg/day.
Elderly
Lower initial doses (e.g., 5-10 mg/day) may be considered, with careful titration based on individual response and tolerability.
Renal_impairment
No dosage adjustment is generally required for patients with renal impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Aripiprazole's efficacy is mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors.
Pharmacokinetics
Onset
Clinical effects may take several weeks to fully manifest.
Excretion
Excreted through both feces (approximately 55%) and urine (approximately 25%).
Half life
Approximately 75 hours for aripiprazole and 94 hours for its active metabolite, dehydroaripiprazole.
Absorption
Well absorbed after oral administration, peak plasma concentration typically within 3-5 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- •Known hypersensitivity to aripiprazole or any component of the formulation.
Drug Interactions
Other CNS depressants (e.g., Alcohol, Benzodiazepines)
Additive sedative effects; caution advised.
Strong CYP2D6 inhibitors (e.g., Quinidine, Fluoxetine)
May increase aripiprazole levels; consider reducing aripiprazole dose.
Strong CYP3A4 inducers (e.g., Carbamazepine, Rifampin)
May decrease aripiprazole levels; consider increasing aripiprazole dose.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole)
May increase aripiprazole levels; consider reducing aripiprazole dose.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tremor, and tachycardia. Management is primarily supportive, including gastric lavage and symptomatic treatment. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Aripiprazole is excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved (DGDA, FDA)
Patent Status
Generic available
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in