Nispore
Generic Name
Gatifloxacin Ophthalmic Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nispore 03 eye drop | ৳ 80.00 | N/A |
Description
Overview of the medicine
Nispore-03 Eye Drop contains Gatifloxacin 0.3%, a fluoroquinolone antibiotic, used to treat bacterial conjunctivitis and other susceptible ocular infections.
Uses & Indications
Dosage
Adults
Days 1-2: Instill one drop into the affected eye(s) every 2 hours while awake, up to 8 times daily. Days 3-7: Instill one drop into the affected eye(s) 4 times daily.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
No specific dosage adjustment is necessary for patients with renal impairment due to minimal systemic absorption.
How to Take
For ophthalmic use only. Wash hands before use. Tilt head back, gently pull down the lower eyelid to form a pocket, instill one drop into the pocket, and then close the eye gently. Do not blink excessively. Avoid touching the dropper tip to the eye or any other surface to prevent contamination.
Mechanism of Action
Gatifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid onset of action in the ocular tissues.
Excretion
Primarily excreted via the kidneys as unchanged drug after systemic absorption.
Half life
Systemic half-life is approximately 7-14 hours, but local ocular kinetics are more relevant for efficacy.
Absorption
Minimal systemic absorption occurs after ocular administration. Peak plasma concentrations are very low and often below the quantifiable limit.
Metabolism
Minimally metabolized; predominantly excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to gatifloxacin, other fluoroquinolones, or any component of the medication.
Drug Interactions
Systemic Medications
Due to minimal systemic absorption, clinically significant systemic drug interactions are unlikely.
Other Ophthalmic Medications
If using other ophthalmic drops, allow at least 5 minutes between administrations to prevent dilution or wash-out of Nispore-03.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Ocular overdose is unlikely to cause systemic toxicity due to minimal absorption. If excessive drops are instilled, rinse the eye with lukewarm water.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Exercise caution when Nispore-03 is administered to a nursing mother, as it is unknown whether gatifloxacin is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to gatifloxacin, other fluoroquinolones, or any component of the medication.
Drug Interactions
Systemic Medications
Due to minimal systemic absorption, clinically significant systemic drug interactions are unlikely.
Other Ophthalmic Medications
If using other ophthalmic drops, allow at least 5 minutes between administrations to prevent dilution or wash-out of Nispore-03.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Ocular overdose is unlikely to cause systemic toxicity due to minimal absorption. If excessive drops are instilled, rinse the eye with lukewarm water.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Exercise caution when Nispore-03 is administered to a nursing mother, as it is unknown whether gatifloxacin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the manufacturing date when unopened. Discard 28 days after opening, or as advised by your pharmacist/doctor.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Clinical trials demonstrated Nispore-03 (Gatifloxacin 0.3%) efficacy and safety in the treatment of bacterial conjunctivitis, showing significant microbial eradication and clinical success rates compared to placebo or other antibiotics.
Lab Monitoring
- No routine lab monitoring is required for ophthalmic gatifloxacin.
Doctor Notes
- Emphasize proper instillation technique to patients.
- Advise patients to complete the full prescribed course of antibiotics, even if symptoms improve quickly.
- Monitor for signs of superinfection or allergic reactions.
Patient Guidelines
- Do not wear contact lenses if you have signs and symptoms of bacterial conjunctivitis.
- Remove contact lenses before instilling Nispore-03 and wait at least 15 minutes before reinserting them.
- Do not discontinue treatment early, even if symptoms improve, to prevent recurrence and resistance.
Missed Dose Advice
If a dose is missed, instill it as soon as you remember, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Nispore-03 may cause temporary blurred vision or other visual disturbances. Patients should be advised to exercise caution when driving or operating machinery until their vision clears.
Lifestyle Advice
- Maintain good ocular hygiene to prevent further infection.
- Avoid rubbing the infected eye(s).
- Do not share eye drops with others.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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