nitalet
Generic Name
Metronidazole 500 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nitalet 500 mg tablet | ৳ 10.03 | N/A |
Description
Overview of the medicine
Nitalet 500 mg Tablet is an antibiotic used to treat a wide variety of bacterial and parasitic infections. It contains Metronidazole as its active ingredient.
Uses & Indications
Dosage
Adults
Dosage varies with infection type, typically 250 mg to 750 mg, 2-3 times daily. Consult a doctor for specific indications.
Elderly
Dosage adjustment may be required in elderly patients.
Renal_impairment
Dose reduction may be necessary in severe renal impairment.
How to Take
Take orally with or without food. Complete the full course of treatment as prescribed.
Mechanism of Action
Metronidazole works by disrupting the DNA synthesis of susceptible anaerobic bacteria and protozoa, leading to cell death.
Pharmacokinetics
Onset
Relatively quick onset of action.
Excretion
Excreted mainly via urine, with some fecal excretion.
Half life
Approximately 8 hours.
Absorption
Well and rapidly absorbed orally.
Metabolism
Primarily hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or any of its components
- First trimester of pregnancy (relative contraindication)
Drug Interactions
Alcohol
Causes a severe disulfiram-like reaction (nausea, vomiting, flushing, headache).
Lithium
Increases plasma concentrations of lithium.
Warfarin
Enhances the anticoagulant effect of warfarin.
Cimetidine
May increase plasma concentrations of metronidazole.
Phenobarbital
May decrease plasma concentrations of metronidazole.
Storage
Store below 30°C in a dry and cool place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose management is symptomatic and supportive.
Pregnancy & Lactation
Generally avoided during the first trimester of pregnancy. Use with caution during lactation as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or any of its components
- First trimester of pregnancy (relative contraindication)
Drug Interactions
Alcohol
Causes a severe disulfiram-like reaction (nausea, vomiting, flushing, headache).
Lithium
Increases plasma concentrations of lithium.
Warfarin
Enhances the anticoagulant effect of warfarin.
Cimetidine
May increase plasma concentrations of metronidazole.
Phenobarbital
May decrease plasma concentrations of metronidazole.
Storage
Store below 30°C in a dry and cool place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose management is symptomatic and supportive.
Pregnancy & Lactation
Generally avoided during the first trimester of pregnancy. Use with caution during lactation as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have been conducted on metronidazole, supporting its efficacy and safety in various infections.
Lab Monitoring
- Liver function tests (LFTs) may be required during prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full course of treatment.
- Advise patients to strictly avoid alcohol.
- Caution patients about neurological side effects, especially peripheral neuropathy.
Patient Guidelines
- Complete the entire course of medication, even if you feel better.
- Avoid alcohol completely during treatment and for at least 48 hours after the last dose.
- Report any severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or confusion in some patients; use caution when driving or operating machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of certain infections.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.