Nitide
Generic Name
Nitidaxin 500 mg Tablet
Manufacturer
Invented Pharma Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nitide 500 mg tablet | ৳ 10.03 | ৳ 100.30 |
Description
Overview of the medicine
Nitide 500 mg Tablet is a broad-spectrum antibiotic indicated for the treatment of various bacterial infections. It works by inhibiting bacterial DNA replication, thereby preventing bacterial growth and spread.
Uses & Indications
Dosage
Adults
500 mg once daily for 7-14 days, depending on the type and severity of infection.
Elderly
No specific dose adjustment is required unless there is significant renal impairment.
Renal_impairment
For creatinine clearance (CrCl) < 30 mL/min, the dose should be reduced to 250 mg once daily.
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Nitidaxin, the active ingredient, selectively inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA integrity and subsequent bacterial cell death.
Pharmacokinetics
Onset
Antibacterial effects typically begin within 1-2 hours of administration.
Excretion
Primarily excreted unchanged in the urine (60-70%) and a smaller portion via feces.
Half life
Approximately 8-10 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Undergoes limited hepatic metabolism to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to nitidaxin or any component of the formulation.
- History of tendon disorders related to fluoroquinolone use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
Theophylline
May increase plasma concentrations of theophylline, necessitating dose adjustment.
Antacids containing aluminum or magnesium
May reduce the absorption of Nitide. Administer Nitide at least 2 hours before or 4 hours after these antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, dizziness, and confusion. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Hemodialysis is not effective.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to nitidaxin or any component of the formulation.
- History of tendon disorders related to fluoroquinolone use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
Theophylline
May increase plasma concentrations of theophylline, necessitating dose adjustment.
Antacids containing aluminum or magnesium
May reduce the absorption of Nitide. Administer Nitide at least 2 hours before or 4 hours after these antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, dizziness, and confusion. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Hemodialysis is not effective.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Patent protected until 2035
Clinical Trials
Phase III clinical trials demonstrated superior efficacy compared to placebo in treating cUTI and CAP. Post-marketing (Phase IV) studies are ongoing to further evaluate long-term safety and rare adverse events.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Liver function tests (baseline and periodic monitoring)
Doctor Notes
- Ensure culture and sensitivity tests are performed before initiating therapy, especially for complicated infections.
- Educate patients on the importance of completing the full antibiotic course to prevent resistance.
- Monitor for signs of tendonitis/tendon rupture, particularly in elderly patients or those on corticosteroids.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Do not share your medication with others.
- Avoid direct sun exposure while on this medication, as it may increase photosensitivity.
- Report any unusual side effects, especially tendon pain or numbness, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Nitide may cause dizziness or lightheadedness. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid alcohol consumption during treatment.
- Follow a balanced diet.
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