Nobesit XR
Generic Name
Nimesulide XR
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nobesit xr 500 mg tablet | ৳ 6.00 | ৳ 60.00 |
| nobesit xr 1000 mg tablet | ৳ 9.00 | ৳ 54.00 |
Description
Overview of the medicine
Nobesit XR is an extended-release formulation of Nimesulide, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation.
Uses & Indications
Dosage
Adults
100 mg once daily (Extended-release tablet).
Elderly
Use with caution; dose reduction may be required based on clinical response and tolerability.
Renal_impairment
Use with caution in mild to moderate renal impairment; contraindicated in severe renal impairment.
How to Take
Take orally with or after food. Do not chew or crush the tablet.
Mechanism of Action
Nimesulide is a preferential cyclooxygenase-2 (COX-2) inhibitor. It works by inhibiting prostaglandin synthesis, thereby reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Onset of action is slower with XR formulation but provides sustained therapeutic levels.
Excretion
Mainly excreted via urine (approximately 50-60%) and feces (20-30%).
Half life
Plasma half-life of nimesulide is typically 2-5 hours, but XR formulation prolongs plasma levels.
Absorption
Well absorbed orally. The extended-release formulation provides sustained release of the active ingredient.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to nimesulide or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic impairment
- Severe renal impairment
- Severe heart failure
- Third trimester of pregnancy
- Children under 12 years of age.
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs
Increased risk of gastrointestinal side effects.
Diuretics, ACE inhibitors, Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, epigastric pain, nausea, vomiting, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Contraindicated during the third trimester of pregnancy due to potential effects on fetal cardiovascular system. Avoid during the first and second trimesters and during lactation unless clearly necessary and potential benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies in Bangladesh
Approval Status
Approved in Bangladesh
Patent Status
Off-patent
Clinical Trials
Extensive clinical data available on Nimesulide's efficacy and safety for various indications, though its use is restricted in some countries due to hepatotoxicity concerns.
Lab Monitoring
- Liver function tests (especially transaminases)
- Renal function tests (e.g., serum creatinine, BUN)
- Complete blood count (for long-term therapy)
Doctor Notes
- Emphasize the shortest possible duration of treatment and the lowest effective dose.
- Monitor liver and renal function, especially in elderly patients or those with pre-existing conditions.
- Educate patients about signs of hepatotoxicity and GI bleeding.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual symptoms, especially yellowing of skin/eyes (jaundice), dark urine, or severe abdominal pain, immediately.
- Take with food to reduce stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption.
- Report any signs of unusual bleeding or bruising.
- Avoid taking other NSAIDs concurrently without consulting your doctor.
- Maintain adequate hydration.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.