Nobokin
Generic Name
Nobokin 200 mg tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nobokin 200 mg tablet | ৳ 300.00 | ৳ 2,400.00 |
Description
Overview of the medicine
Nobokin 200 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Usually 200-400 mg once daily, depending on the severity and type of infection. Duration of treatment varies from 5 to 14 days.
Elderly
No specific dose adjustment is required based solely on age, but renal function should be assessed, and dose adjusted if needed.
Renal_impairment
Dosage adjustment is necessary in patients with creatinine clearance less than 50 mL/min. Consult prescribing information for specific guidelines.
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Nobokin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours for antibacterial action.
Excretion
Primarily excreted unchanged by the kidneys (renal excretion).
Half life
Approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are usually reached within 1-2 hours.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Nobokin or other fluoroquinolones
- History of tendon disorders related to fluoroquinolone administration
- Epilepsy or other seizure disorders
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR carefully.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of CNS stimulation and convulsive seizures.
Antacids containing aluminum or magnesium, sucralfate, iron or zinc supplements
May decrease the absorption of Nobokin. Administer Nobokin at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Hemodialysis or peritoneal dialysis is not effective in removing fluoroquinolones.
Pregnancy & Lactation
Nobokin is generally not recommended during pregnancy and lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk.
Side Effects
Contraindications
- Hypersensitivity to Nobokin or other fluoroquinolones
- History of tendon disorders related to fluoroquinolone administration
- Epilepsy or other seizure disorders
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR carefully.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of CNS stimulation and convulsive seizures.
Antacids containing aluminum or magnesium, sucralfate, iron or zinc supplements
May decrease the absorption of Nobokin. Administer Nobokin at least 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Hemodialysis or peritoneal dialysis is not effective in removing fluoroquinolones.
Pregnancy & Lactation
Nobokin is generally not recommended during pregnancy and lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Nobokin has undergone various clinical trials demonstrating its efficacy and safety in bacterial infections, often showing comparable outcomes to other established fluoroquinolones. Post-marketing surveillance continues to monitor long-term effects.
Lab Monitoring
- Renal function tests (especially in elderly or renally impaired patients)
- Blood glucose levels (in diabetic patients due to risk of dysglycemia)
- INR (for patients on warfarin)
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients.
- Educate patients on the black box warnings, particularly regarding tendon rupture and neuropathy symptoms.
- Consider potential drug interactions, especially with warfarin, antacids, and NSAIDs.
- Avoid use in patients with a history of myasthenia gravis, as it may exacerbate muscle weakness.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent resistance.
- Avoid excessive exposure to sunlight or artificial UV light and use sunscreen.
- Report any tendon pain, swelling, or weakness immediately to your doctor.
- Do not take antacids or iron/zinc supplements within 2-6 hours of taking Nobokin.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Nobokin may cause dizziness or lightheadedness. Exercise caution when driving or operating machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid strenuous physical activity that could strain tendons during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.