Noficon
Generic Name
Fluconazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| noficon 200 mg capsule | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Noficon 200 mg Capsule contains Fluconazole, an antifungal medication used to treat various fungal infections, including vaginal candidiasis, oral thrush, and systemic candidal infections.
Uses & Indications
Dosage
Adults
For vaginal candidiasis: 150 mg single oral dose. For oropharyngeal candidiasis: 50-100 mg once daily for 7-14 days. For systemic infections: 200-400 mg once daily, duration based on infection type and severity.
Elderly
Dosage adjustments are generally not necessary in elderly patients unless there is evidence of renal impairment.
Renal_impairment
In patients with creatinine clearance <50 mL/min, the dose should be reduced by 50% after a normal initial loading dose.
How to Take
Noficon capsules can be taken orally, with or without food. Swallow the capsule whole with a glass of water. Do not chew or crush.
Mechanism of Action
Fluconazole inhibits fungal cytochrome P450-dependent 14α-demethylation of lanosterol, an essential step in fungal ergosterol biosynthesis. This leads to an accumulation of 14α-methyl sterols and a decrease in ergosterol, disrupting the fungal cell membrane integrity and function.
Pharmacokinetics
Onset
Clinical effects usually begin within 1-2 days, though full resolution of symptoms may take longer depending on the infection type.
Excretion
The primary route of elimination is renal, with approximately 80% of the dose excreted unchanged in the urine.
Half life
The plasma elimination half-life is approximately 30 hours, allowing for once-daily dosing for many indications.
Absorption
Fluconazole is well absorbed after oral administration, with systemic bioavailability typically exceeding 90%. Peak plasma concentrations are achieved within 0.5-1.5 hours.
Metabolism
Fluconazole is minimally metabolized (approximately 11% to 15% of the dose is metabolized to less active or inactive metabolites) in humans.
Side Effects
Contraindications
- Hypersensitivity to fluconazole, other azole derivatives, or any component of the formulation.
- Concomitant administration of terfenadine, cisapride, astemizole, pimozide, or quinidine with fluconazole (due to risk of QTc prolongation and serious cardiac arrhythmias).
Drug Interactions
Warfarin
Increased prothrombin time, monitor INR.
Phenytoin
Increased phenytoin serum concentrations, monitor levels.
Rifampicin
Decreased fluconazole plasma concentrations.
Cyclosporine, Tacrolimus
Increased plasma concentrations of immunosuppressants.
Oral hypoglycemics (sulfonylureas)
Increased plasma concentrations of sulfonylureas, risk of hypoglycemia.
Storage
Store in a dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered. Hemodialysis significantly reduces plasma levels of fluconazole and may be beneficial.
Pregnancy & Lactation
Fluconazole is generally avoided in pregnancy, especially in the first trimester, due to potential risk of congenital malformations with chronic high doses. It is excreted into breast milk; therefore, caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Fluconazole's efficacy and safety in various fungal infections, leading to its widespread approval and use globally. Post-marketing surveillance continues to monitor its long-term effects and safety profile.
Lab Monitoring
- Liver function tests (baseline and periodically, especially in patients with pre-existing hepatic impairment or prolonged therapy).
- Renal function tests (for dosage adjustments in renal impairment).
- Electrolytes, particularly potassium (due to risk of QT prolongation).
- INR in patients concurrently on warfarin.
Doctor Notes
- Fluconazole has a long half-life, allowing for convenient once-daily or even single-dose regimens for many indications.
- Careful monitoring of liver function tests (LFTs) is crucial, especially in patients with pre-existing hepatic impairment or those receiving prolonged therapy.
- Be aware of significant drug interactions, particularly with agents that prolong the QT interval or are substrates of CYP2C9, CYP2C19, and CYP3A4.
Patient Guidelines
- Take the full course of medication as prescribed by your doctor, even if your symptoms improve.
- Inform your doctor about all other medications, herbal products, and supplements you are taking to avoid potential drug interactions.
- Report any new or worsening side effects, especially severe rash, yellowing of skin/eyes, or unusual fatigue, immediately to your doctor.
- Maintain good hygiene to prevent recurrence of fungal infections.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Noficon may cause dizziness or seizures in some patients. If you experience these side effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid sharing personal items like towels, clothing, or footwear that might spread fungal infections.
- For vaginal candidiasis, wear loose-fitting, cotton underwear and avoid tight clothing.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.