Nohist
Generic Name
Desloratadine
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nohist 10 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Desloratadine is a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, watery eyes, and itching. It is also used to treat chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
10 mg once daily, with or without food.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal function.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), consider 10 mg every other day.
How to Take
Nohist 10 mg Tablet should be taken orally, swallowed whole with water. It can be taken with or without food.
Mechanism of Action
Desloratadine is a potent, selective, peripheral H1-receptor antagonist. It effectively blocks the action of histamine, a chemical responsible for allergic symptoms, without causing significant drowsiness.
Pharmacokinetics
Onset
Within 1 hour for antihistaminic effects.
Excretion
Eliminated primarily via urine (40%) and feces (40%) as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
- Patients with a history of severe allergic reactions to similar medications.
Drug Interactions
Alcohol
No potentiation of alcohol-induced impairment of psychomotor performance was found in clinical trials.
Erythromycin
Co-administration with erythromycin led to increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Ketoconazole
Concomitant administration with ketoconazole resulted in increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Fluoxetine, Cimetidine
May lead to increased exposure to desloratadine; however, no clinically relevant adverse events were observed.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In the event of overdose, symptomatic and supportive treatment is recommended. Desloratadine is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
- Patients with a history of severe allergic reactions to similar medications.
Drug Interactions
Alcohol
No potentiation of alcohol-induced impairment of psychomotor performance was found in clinical trials.
Erythromycin
Co-administration with erythromycin led to increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Ketoconazole
Concomitant administration with ketoconazole resulted in increased plasma concentrations of desloratadine and 3-hydroxydesloratadine.
Fluoxetine, Cimetidine
May lead to increased exposure to desloratadine; however, no clinically relevant adverse events were observed.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In the event of overdose, symptomatic and supportive treatment is recommended. Desloratadine is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Patent expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Desloratadine for the treatment of allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No specific routine laboratory monitoring is required for patients taking Desloratadine at recommended doses. Liver function tests may be considered in patients with pre-existing liver impairment.
Doctor Notes
- Advise patients that while generally non-drowsy, some individuals may experience mild sedation. Caution should be exercised when driving or operating machinery until individual response is known.
- Consider dosage adjustment in patients with severe renal impairment (CrCl < 30 mL/min).
- Educate patients on proper storage and to keep out of reach of children.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor or pharmacist about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any new or worsening symptoms, or any unusual side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Nohist (Desloratadine) is generally considered a non-drowsy antihistamine. However, individual responses to medications vary. Patients should exercise caution when performing tasks requiring mental alertness, such as driving or operating machinery, until they know how the medicine affects them.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good indoor air quality and hygiene to minimize exposure to dust mites, pet dander, and mold.
- Consult your doctor for non-pharmacological methods to manage allergies.
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