Norfen
Generic Name
Norfen 50 mg tablet
Manufacturer
Example Pharmaceutical Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norfen 50 mg tablet | ৳ 1.00 | ৳ 10.00 |
Description
Overview of the medicine
Norfen 50 mg tablet contains Norfloxacin, a fluoroquinolone antibiotic used to treat a variety of bacterial infections, particularly those affecting the urinary tract. While Norfloxacin is commonly available in 400 mg strength, this 50 mg formulation may be used for specific low-dose requirements or in combination therapies as prescribed by a physician.
Uses & Indications
Dosage
Adults
The usual adult dosage for Norfloxacin is typically 400 mg twice daily. For Norfen 50 mg, specific dosing for adults must be determined by a physician based on the indication and severity of infection. For uncomplicated UTIs, a lower dose might be considered, but 50 mg is generally not a standard monotherapy dose for most systemic infections.
Elderly
No specific dosage adjustment is required based on age, but renal function should be assessed, and dosage adjusted if renal impairment is present.
Renal_impairment
For patients with creatinine clearance <30 mL/min/1.73 m², dosage adjustments are usually necessary, typically reducing the dose or extending the dosing interval. Consult a physician for specific dosage instructions for Norfen 50 mg in renal impairment.
How to Take
Norfen 50 mg tablet should be taken orally with a glass of water, usually on an empty stomach (at least one hour before or two hours after a meal or dairy products). Do not take with antacids, iron, or zinc preparations. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Norfloxacin exerts its bactericidal action by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA processes and ultimately bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours (onset of antimicrobial action).
Excretion
Primarily excreted unchanged in urine and feces. Renal excretion accounts for approximately 30%.
Half life
3-4 hours; can be prolonged in renal impairment.
Absorption
Approximately 30-40% of an oral dose is absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Minimally metabolized; hepatic metabolism produces minor inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Norfloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with quinolone use
- Children and adolescents (due to risk of arthropathy)
- Pregnancy and lactation
Drug Interactions
Caffeine
Reduced clearance of caffeine, leading to increased levels and potential side effects.
Warfarin
Potentiation of anticoagulant effect, increased risk of bleeding.
Theophylline
Increased plasma levels of theophylline, leading to toxicity.
Antacids, iron, zinc preparations
Can reduce absorption of Norfloxacin; take Norfloxacin 2-3 hours before or after these preparations.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May increase the risk of CNS stimulation and convulsive seizures.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote exists. Treatment should be symptomatic and supportive. Gastric lavage and hydration may be helpful. Patients should be closely monitored for adverse effects.
Pregnancy & Lactation
Pregnancy Category C. Norfloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and should not be used by nursing mothers due to the risk of serious adverse reactions in infants. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on storage conditions and specific formulation.
Availability
Available in pharmacies
Approval Status
Approved (for Norfloxacin)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Norfloxacin for various bacterial infections. Specific trials for a 50 mg formulation would be required to determine its unique therapeutic role.
Lab Monitoring
- Renal function tests (especially in elderly or renally impaired patients)
- Liver function tests (if prolonged therapy or suspected hepatic dysfunction)
- Complete blood count (occasionally, if prolonged therapy)
Doctor Notes
- Confirm bacterial etiology before prescribing.
- Counsel patients on potential severe adverse reactions including tendinitis/tendon rupture and neurological effects.
- Advise patients to report any musculoskeletal pain, numbness, tingling, or weakness immediately.
- Ensure full course completion to prevent resistance.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the entire course of medication, even if you feel better.
- Drink plenty of fluids while taking this medication.
- Avoid taking antacids, iron supplements, or dairy products close to your Norfen dose.
- Protect yourself from sun exposure as Norfen can increase photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Norfen may cause dizziness, lightheadedness, or visual disturbances. If you experience these effects, avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection, especially for UTIs.
- Stay well-hydrated.
- Avoid excessive sun exposure.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.