Norflocin
Generic Name
norflu-05-mg-tablet
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norflu 05 mg tablet | ৳ 1.06 | N/A |
Description
Overview of the medicine
Norflu-05-mg-tablet contains Norfloxacin, a fluoroquinolone antibiotic used to treat bacterial infections. While 5 mg is an unusually low dose for systemic treatment, it might be formulated for specific, localized, or highly sensitive conditions, or could be a misinterpretation of a standard strength.
Uses & Indications
Dosage
Adults
Typically, for general bacterial infections, Norfloxacin is prescribed at 400 mg twice daily. A 5 mg dose is highly specific and would require explicit medical consultation for appropriate use, likely for very localized or prophylactic purposes.
Elderly
Dosage adjustment may be needed based on renal function; consult a physician.
Renal_impairment
Dosage should be reduced in patients with significant renal impairment; follow medical advice.
How to Take
Take orally with a glass of water, at least one hour before or two hours after a meal or dairy products. Do not take with antacids containing magnesium or aluminum.
Mechanism of Action
Norfloxacin acts by inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Approximately 30-40% of the administered dose is excreted unchanged in the urine within 24 hours. Small amounts are excreted in feces.
Half life
3-4 hours
Absorption
Rapidly but incompletely absorbed from the gastrointestinal tract (30-40%). Peak plasma concentrations occur 1-2 hours after dosing.
Metabolism
Minimally metabolized in the liver (less than 10% of dose).
Side Effects
Contraindications
- Hypersensitivity to Norfloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Children under 18 years of age (due to cartilage damage risk)
Drug Interactions
NSAIDs
Increased risk of CNS stimulation and convulsions.
Warfarin
Potentiation of anticoagulant effects.
Theophylline
Increased plasma levels of Theophylline.
Antacids (Mg/Al)
Reduced absorption of Norfloxacin.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, and in severe cases, renal toxicity. Treatment is supportive; gastric lavage and activated charcoal may be considered. Maintain adequate hydration.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Use only if benefits outweigh risks and under strict medical supervision.
Side Effects
Contraindications
- Hypersensitivity to Norfloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Children under 18 years of age (due to cartilage damage risk)
Drug Interactions
NSAIDs
Increased risk of CNS stimulation and convulsions.
Warfarin
Potentiation of anticoagulant effects.
Theophylline
Increased plasma levels of Theophylline.
Antacids (Mg/Al)
Reduced absorption of Norfloxacin.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, and in severe cases, renal toxicity. Treatment is supportive; gastric lavage and activated charcoal may be considered. Maintain adequate hydration.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to potential risks to the fetus/infant. Use only if benefits outweigh risks and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Norfloxacin's efficacy and safety in various bacterial infections, particularly UTIs. However, trials specific to a 5 mg oral tablet for systemic use are not commonly documented for Norfloxacin.
Lab Monitoring
- Renal function tests (especially in elderly or impaired patients)
- Liver function tests
- Blood counts (if long-term use)
Doctor Notes
- Counsel patients about the risk of tendon rupture and neuropathy.
- Ensure complete course adherence to minimize resistance.
- Monitor renal function, especially in elderly and those with kidney impairment.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Avoid excessive sunlight exposure.
- Drink plenty of fluids.
- Report any tendon pain or unusual tingling/numbness immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, which can impair ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Avoid alcohol during treatment.
- Stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.