Norgest
Generic Name
Norgestrel
Manufacturer
Generic Manufacturer
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norgest 003 mg tablet | ৳ 19.95 | N/A |
Description
Overview of the medicine
Norgestrel 0.03 mg is a progestin-only oral contraceptive (mini-pill) used to prevent pregnancy by primarily affecting cervical mucus and the uterine lining.
Uses & Indications
Dosage
Adults
One tablet orally once daily, continuously, at the same time each day, starting on the first day of menstruation.
Elderly
Not indicated for postmenopausal women. No specific dosage adjustment for elderly women if used for specific conditions but generally not applicable for contraception.
Renal_impairment
No specific dosage adjustment is usually required for renal impairment.
How to Take
Take orally with water, at the same time each day without interruption between packs. It is crucial to maintain strict adherence to the dosing schedule.
Mechanism of Action
Primarily by thickening cervical mucus to prevent sperm penetration, altering the endometrium to inhibit implantation, and to some extent, suppressing ovulation.
Pharmacokinetics
Onset
Contraceptive effect generally established after 7 days of continuous use, or immediately if started on day 1 of menstruation.
Excretion
Excreted through urine and feces as metabolites.
Half life
Approximately 11-45 hours (variable, active metabolite half-life about 20-45 hours).
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via hydroxylation and conjugation. The main active metabolite is levonorgestrel.
Side Effects
Contraindications
- •Known or suspected pregnancy
- •Undiagnosed abnormal vaginal bleeding
- •Breast cancer (current or history)
- •Hepatic impairment or liver tumors (benign or malignant)
- •Known hypersensitivity to norgestrel or any component of the tablet
- •Active venous thromboembolic disorder (less common for progestin-only pills but still a consideration)
Drug Interactions
St. John's Wort
Can reduce contraceptive effectiveness.
Ritonavir, Nevirapine
May decrease progestin levels.
Antibiotics (e.g., Rifampicin, Griseofulvin)
May decrease contraceptive efficacy by altering gut flora or inducing hepatic enzymes.
Anticonvulsants (e.g., Phenytoin, Carbamazepine, Barbiturates)
May decrease the efficacy of norgestrel by inducing hepatic enzymes.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with oral contraceptives may cause nausea, vomiting, and withdrawal bleeding in females. Serious ill effects are generally not anticipated.
Pregnancy & Lactation
Contraindicated in pregnancy. Can be used during lactation as it does not significantly affect the quantity or quality of breast milk and is considered compatible with breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, check specific packaging for details.
Availability
Pharmacies, Clinics
Approval Status
Approved
Patent Status
Patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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