Norglic
Generic Name
norglic-80-mg-tablet
Manufacturer
A B C Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norglic 80 mg tablet | ৳ 6.00 | N/A |
Description
Overview of the medicine
Norglic 80 mg tablet is an oral antidiabetic medication used to lower blood glucose levels in patients with type 2 diabetes mellitus. It contains Gliclazide, a sulfonylurea, which stimulates insulin secretion from the pancreatic beta cells.
Uses & Indications
Dosage
Adults
Initial dose is usually 40-80 mg daily, taken with breakfast. Dosage can be gradually increased in steps of 40-80 mg, up to a maximum of 320 mg daily, usually divided into two doses.
Elderly
Similar to adult dosage, but titration should be done carefully, starting with a lower dose.
Renal_impairment
In mild to moderate renal impairment, no dose adjustment is usually required. In severe impairment, use with caution, and dosage may need to be reduced.
How to Take
Norglic 80 mg tablet should be taken orally, preferably with breakfast. It should be swallowed whole with water and not crushed or chewed.
Mechanism of Action
Gliclazide acts primarily by stimulating insulin release from the pancreatic β-cells. It binds to the sulfonylurea receptor (SUR1) on the β-cell membrane, leading to the closure of ATP-sensitive potassium channels. This depolarization opens voltage-dependent calcium channels, increasing intracellular calcium, which triggers insulin secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in the urine (60-70%) as metabolites, and a small amount in feces (10-20%).
Half life
Approximately 8-20 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 4-6 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas or any excipients.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis, diabetic precoma and coma.
- Severe renal or hepatic insufficiency.
- Concomitant treatment with miconazole.
Drug Interactions
Miconazole
Enhances the hypoglycemic effect, potentially leading to severe hypoglycemia.
Beta-blockers
May mask symptoms of hypoglycemia and potentiate the hypoglycemic effect.
Phenylbutazone, Alcohol, Sulfonamides
Potentiate the hypoglycemic effect of Gliclazide.
Corticosteroids, Danazol, Chlorpromazine
May reduce the hypoglycemic effect, requiring higher doses of Gliclazide.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypoglycemia. Management includes administration of glucose (oral or intravenous), close monitoring of blood glucose levels, and supportive care.
Pregnancy & Lactation
Not recommended during pregnancy as insulin is preferred for managing diabetes in pregnant women. Should not be used during breastfeeding due to potential risk of neonatal hypoglycemia.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas or any excipients.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis, diabetic precoma and coma.
- Severe renal or hepatic insufficiency.
- Concomitant treatment with miconazole.
Drug Interactions
Miconazole
Enhances the hypoglycemic effect, potentially leading to severe hypoglycemia.
Beta-blockers
May mask symptoms of hypoglycemia and potentiate the hypoglycemic effect.
Phenylbutazone, Alcohol, Sulfonamides
Potentiate the hypoglycemic effect of Gliclazide.
Corticosteroids, Danazol, Chlorpromazine
May reduce the hypoglycemic effect, requiring higher doses of Gliclazide.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypoglycemia. Management includes administration of glucose (oral or intravenous), close monitoring of blood glucose levels, and supportive care.
Pregnancy & Lactation
Not recommended during pregnancy as insulin is preferred for managing diabetes in pregnant women. Should not be used during breastfeeding due to potential risk of neonatal hypoglycemia.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Gliclazide has been extensively studied in various clinical trials demonstrating its efficacy and safety in managing type 2 diabetes, including studies on cardiovascular outcomes (e.g., ADVANCE trial).
Lab Monitoring
- Regular monitoring of blood glucose levels (fasting and postprandial).
- HbA1c levels to assess long-term glycemic control.
- Liver function tests (LFTs) periodically.
- Renal function tests periodically.
Doctor Notes
- Educate patients on hypoglycemia recognition and management.
- Monitor renal and hepatic function, especially in elderly patients.
- Regularly assess HbA1c to ensure adequate glycemic control.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Be aware of the symptoms of hypoglycemia and how to manage them.
- Maintain a regular diet and exercise routine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Patients should be aware of the risk of hypoglycemia, which can impair the ability to drive or operate machinery. If symptoms of hypoglycemia occur, avoid these activities.
Lifestyle Advice
- Follow a balanced diet plan recommended by your doctor or dietitian.
- Engage in regular physical activity.
- Monitor your blood glucose regularly at home.
- Avoid smoking and limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.