Norium
Generic Name
Noripram-10-mg-tablet
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norium 10 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Norium-10-mg-tablet is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat major depressive disorder, anxiety disorders, and panic disorder by helping to restore the balance of serotonin in the brain.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily. May be increased to 20 mg once daily after one week, depending on response. Maximum recommended dose is 20 mg/day.
Elderly
Initial dose 5 mg once daily. Max dose typically 10 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution advised in severe impairment.
How to Take
Take orally once daily, preferably in the morning, with or without food. Do not chew or crush the tablet; swallow whole.
Mechanism of Action
Norium selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Initial antidepressant effects may be seen within 1-2 weeks, full therapeutic effect usually takes 4-6 weeks.
Excretion
Excreted primarily in urine (approx. 60%) and feces (approx. 40%) as metabolites.
Half life
Approximately 20-24 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, peak plasma concentrations typically achieved within 4-8 hours. Bioavailability is high and not significantly affected by food.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes, into active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Noripram or any component of the tablet.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Pimozide
Concomitant use contraindicated due to potential for QT prolongation.
Warfarin
Potential for increased bleeding risk due to altered platelet function.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal bleeding.
Triptans (e.g., Sumatriptan)
Increased risk of serotonin syndrome.
Storage
Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and rarely, convulsions or serotonin syndrome. Management is symptomatic and supportive; maintain airway, monitor cardiac and vital signs, and provide general supportive measures.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Noripram is excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Noripram or any component of the tablet.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
Pimozide
Concomitant use contraindicated due to potential for QT prolongation.
Warfarin
Potential for increased bleeding risk due to altered platelet function.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal bleeding.
Triptans (e.g., Sumatriptan)
Increased risk of serotonin syndrome.
Storage
Store below 30°C, in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and rarely, convulsions or serotonin syndrome. Management is symptomatic and supportive; maintain airway, monitor cardiac and vital signs, and provide general supportive measures.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Noripram is excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
Clinical Trials
Extensive clinical trials (Phase I, II, III) have demonstrated Norium's efficacy and safety in the treatment of major depressive disorder and various anxiety disorders. Post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Periodic monitoring of liver function tests may be considered in patients with hepatic impairment.
- Monitor serum sodium levels, especially in elderly patients or those on diuretics.
Doctor Notes
- Educate patients on the delayed onset of action and the importance of adherence.
- Monitor for signs of suicidality, especially at the initiation of therapy and dose changes.
- Advise patients against abrupt discontinuation and provide a tapering schedule when appropriate.
- Consider potential drug interactions, especially with MAOIs and other serotonergic agents.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Norium abruptly, as this can lead to withdrawal symptoms; gradual tapering is necessary.
- Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.
- It may take several weeks to feel the full benefits of this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Norium may cause drowsiness, dizziness, or blurred vision. Patients should be advised to exercise caution when driving or operating machinery until they know how Norium affects them.
Lifestyle Advice
- Avoid alcohol consumption while on Norium.
- Engage in regular physical activity and maintain a balanced diet.
- Practice stress-reduction techniques.
- Get adequate sleep.
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