Norline
Generic Name
Norethisterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norline 2 mg injection | ৳ 250.00 | N/A |
Description
Overview of the medicine
Norline (Norethisterone) is a synthetic progestogen primarily used in hormone replacement therapy, contraception, and treatment of various menstrual disorders like dysfunctional uterine bleeding, amenorrhea, and endometriosis.
Uses & Indications
Dosage
Adults
For dysfunctional uterine bleeding: 5-10 mg daily for 10 days. For amenorrhea: 5-10 mg daily for 5-10 days, usually after estrogen priming. For endometriosis: 10 mg daily for 6-9 months.
Elderly
No specific dose adjustments, but caution in patients with hepatic impairment.
Renal_impairment
No specific dose adjustments required.
How to Take
Oral administration, preferably with food to reduce gastrointestinal upset. Should be taken at the same time each day.
Mechanism of Action
Norethisterone acts by binding to progesterone receptors, mimicking the effects of natural progesterone. It suppresses ovulation, thickens cervical mucus, and thins the uterine lining.
Pharmacokinetics
Onset
Effects usually observed within a few hours to days, depending on indication.
Excretion
Excreted mainly in urine (50-70%) and feces (20-40%) as metabolites.
Half life
About 5-10 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, achieving peak plasma levels within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by reduction and hydroxylation, followed by conjugation.
Side Effects
Contraindications
- Pregnancy
- Breast cancer or other hormone-dependent cancers
- Severe liver disease or tumors
- Undiagnosed vaginal bleeding
- History of thromboembolic disorders
Drug Interactions
Ritonavir
Can affect norethisterone metabolism.
Rifampicin
Strong enzyme inducer, significantly reduces norethisterone levels.
Phenobarbital, Phenytoin, Carbamazepine
May decrease the efficacy of norethisterone by inducing hepatic enzymes.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, and vaginal bleeding. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated during pregnancy. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy in contraception, menstrual disorders, and hormone replacement therapy. Evidence supports its use for approved indications.
Lab Monitoring
- Regular blood pressure monitoring
- Liver function tests (periodically, especially with long-term use)
- Lipid profile
Doctor Notes
- Assess patient's cardiovascular risk factors before prescribing.
- Consider alternative contraception methods if patient has a history of thromboembolic events.
- Regular follow-up for long-term users.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual bleeding or severe side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Norline is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet and regular exercise.
- Avoid smoking, especially if you are taking this for contraception, as it increases the risk of serious cardiovascular side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.