Nosedex
Generic Name
Fexofenadine Hydrochloride 120 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nosedex 120 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Nosedex 120 mg Tablet contains Fexofenadine Hydrochloride, a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives. It works by blocking histamine, a natural substance the body produces during an allergic reaction.
Uses & Indications
Dosage
Adults
For Seasonal Allergic Rhinitis: 120 mg or 180 mg orally once daily. For Chronic Idiopathic Urticaria: 180 mg orally once daily.
Elderly
No specific dosage adjustment is recommended in elderly patients with normal renal function. Use with caution in patients with impaired renal function.
Renal_impairment
For adults and children 12 years and older with impaired renal function: 60 mg orally once daily for seasonal allergic rhinitis and chronic idiopathic urticaria.
How to Take
Take orally with water, preferably before a meal. Do not take with fruit juices (e.g., grapefruit, orange, apple) as they may reduce the absorption of fexofenadine.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It competitively binds to and inhibits the activity of histamine at H1 receptors, thereby preventing the symptoms associated with histamine release in allergic reactions.
Pharmacokinetics
Onset
Antihistaminic effects generally begin within 1 hour.
Excretion
Primarily excreted unchanged in feces (80%) and urine (11-12%).
Half life
Elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1-3 hours.
Metabolism
Undergoes negligible hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
Can increase plasma levels of fexofenadine, but this is not associated with an increase in side effects.
Fruit Juices (Grapefruit, Orange, Apple)
Can reduce the oral bioavailability of fexofenadine. Avoid taking fexofenadine with these juices.
Antacids containing aluminum and magnesium
May decrease the absorption of fexofenadine. It is recommended to separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. In case of overdose, initiate general symptomatic and supportive measures. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria, showing it to be well-tolerated and providing effective symptom relief.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients on fexofenadine.
Doctor Notes
- Advise patients about the importance of avoiding fruit juices around the time of fexofenadine administration.
- Consider dosage adjustment in patients with significant renal impairment.
- Reassure patients that fexofenadine is a non-sedating antihistamine, but to monitor for individual response.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Avoid taking with fruit juices (grapefruit, orange, apple) as they can reduce the drug's effectiveness.
- Inform your doctor or pharmacist about all other medications, herbal products, and supplements you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Driving Precautions
Although generally non-drowsy, some individuals may experience dizziness or drowsiness. Exercise caution when driving or operating machinery until you know how this medication affects you.
Lifestyle Advice
- Identify and avoid known allergens to help manage your allergy symptoms.
- Maintain adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.