Nospot
Generic Name
Adapalene (0.1%) Cream
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nospot 001 4 cream | ৳ 200.00 | N/A |
Description
Overview of the medicine
Nospot 0.1% Cream contains Adapalene, a topical retinoid used in the treatment of acne vulgaris. It helps to unclog pores and reduce inflammation, leading to clearer skin.
Uses & Indications
Dosage
Adults
Apply a thin layer of cream to the affected areas of the face and/or trunk once daily in the evening after washing.
Elderly
No specific dosage adjustment required.
Renal_impairment
No specific dosage adjustment required.
How to Take
For topical use only. Apply to clean, dry skin. Avoid contact with eyes, lips, and mucous membranes. Wash hands after application.
Mechanism of Action
Adapalene modulates cellular differentiation, keratinization, and inflammatory processes, all of which are important in the pathogenesis of acne vulgaris. It binds to specific retinoic acid nuclear receptors and has comedolytic and anti-inflammatory effects.
Pharmacokinetics
Onset
Initial improvement seen within 1-4 weeks, significant improvement after 8-12 weeks.
Excretion
Mainly excreted in the bile.
Half life
Not determined due to minimal systemic absorption.
Absorption
Systemic absorption through skin is minimal; plasma concentrations are typically below the quantifiable limit.
Metabolism
Primarily metabolized in the liver via O-demethylation, hydroxylation, and conjugation.
Side Effects
Contraindications
- •Hypersensitivity to adapalene or any component of the cream
- •Pregnancy
Drug Interactions
Cosmetics
Use with caution with cosmetics that have a strong drying effect.
Other topical agents
Avoid concomitant use with other potentially irritating topical products or those with a strong drying or abrasive effect (e.g., salicylic acid, alpha hydroxy acids, benzoyl peroxide), unless directed by a doctor, due to increased risk of irritation.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to produce systemic effects due to minimal absorption. Excessive application may result in marked redness, peeling, or discomfort. Management includes supportive care and symptomatic treatment.
Pregnancy & Lactation
Not recommended during pregnancy due to potential teratogenic effects. Use with caution in breastfeeding mothers; consult a doctor. Avoid applying to the chest area if breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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