Not applicable (generic)
Generic Name
Dextrose
Manufacturer
Various
Country
Global
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Description
Overview of the medicine
Dextrose is a simple sugar (glucose) used as a source of energy, to treat low blood sugar (hypoglycemia), and as a component in fluid replacement therapy.
Uses & Indications
Dosage
Adults
Varies greatly depending on indication and concentration (e.g., 5-25g IV for hypoglycemia, 5% or 10% solutions for fluid maintenance).
Elderly
Similar to adults, but monitor for fluid overload and electrolyte imbalance.
Renal_impairment
Use with caution; monitor fluid balance and electrolytes.
How to Take
Intravenous infusion. For severe hypoglycemia, bolus injection of higher concentrations (e.g., 25% or 50%).
Mechanism of Action
Dextrose provides readily available energy to cells by increasing blood glucose levels. It is metabolized to carbon dioxide and water, releasing energy.
Pharmacokinetics
Onset
Immediate (minutes for IV).
Excretion
Not excreted unchanged; metabolic end products (CO2 and water) are excreted.
Half life
Not a distinct half-life for dextrose itself; it's rapidly metabolized.
Absorption
Rapidly absorbed when administered intravenously.
Metabolism
Metabolized to carbon dioxide and water via glycolysis and Krebs cycle.
Side Effects
Contraindications
- •Diabetic coma (unless hypoglycemia is also present).
- •Anuria (for significant volumes).
- •Intracranial or intraspinal hemorrhage.
- •Known allergy to corn or corn products (rare, as dextrose is often corn-derived).
Drug Interactions
Insulin
May lower blood glucose when co-administered.
Certain diuretics
Can affect serum electrolyte levels when given with certain diuretics.
Storage
Store at room temperature (15-30°C), protect from freezing and excessive heat. Do not use if solution is cloudy or contains particles.
Overdose
Symptoms include hyperglycemia, glucosuria, fluid overload, and electrolyte disturbances. Treatment involves discontinuing dextrose, administering insulin if hyperglycemia is severe, and managing fluid/electrolyte balance.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when indicated, but monitor fluid and electrolyte balance.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as per manufacturer specifications
Availability
Hospitals, pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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