Novelta
Generic Name
Albendazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novelta 480 mg chewable tablet | ৳ 3.01 | ৳ 30.10 |
Description
Overview of the medicine
Novelta 480 mg Chewable Tablet contains Albendazole, an anthelmintic medication used to treat various parasitic worm infections.
Uses & Indications
Dosage
Adults
For most intestinal worm infections: One 480 mg tablet as a single dose. For neurocysticercosis/hydatid: 480 mg twice daily with meals for 8-30 days, or as directed by physician.
Elderly
No specific dose adjustment is generally required, but caution is advised in those with liver impairment.
Renal_impairment
No specific dosage adjustment is required for renal impairment, as excretion is primarily biliary.
How to Take
Chew the tablet completely before swallowing, preferably with a fatty meal to enhance absorption.
Mechanism of Action
Albendazole acts by inhibiting microtubule polymerization, leading to disruption of parasite motility, glucose uptake, and ultimately death.
Pharmacokinetics
Onset
Varies with target parasite; typically within hours for systemic effect of metabolites.
Excretion
Mainly via bile and urine as metabolites.
Half life
Primary metabolite (Albendazole sulfoxide): 8-12 hours.
Absorption
Poorly absorbed orally (<5%); absorption is enhanced with fatty meals.
Metabolism
Extensively metabolized in the liver to albendazole sulfoxide (active metabolite) and then to albendazole sulfone (inactive).
Side Effects
Contraindications
- Hypersensitivity to Albendazole or other benzimidazoles
- Pregnancy (especially first trimester)
- Children under 6 years for neurocysticercosis
Drug Interactions
Cimetidine
May increase Albendazole sulfoxide levels.
Praziquantel
May increase Albendazole sulfoxide levels.
Dexamethasone
May increase Albendazole sulfoxide levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea), headache, dizziness, and fatigue. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Category C in pregnancy. Not recommended during pregnancy, especially first trimester. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Albendazole is excreted in breast milk, caution is advised in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to Albendazole or other benzimidazoles
- Pregnancy (especially first trimester)
- Children under 6 years for neurocysticercosis
Drug Interactions
Cimetidine
May increase Albendazole sulfoxide levels.
Praziquantel
May increase Albendazole sulfoxide levels.
Dexamethasone
May increase Albendazole sulfoxide levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal disturbances (nausea, vomiting, diarrhea), headache, dizziness, and fatigue. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Category C in pregnancy. Not recommended during pregnancy, especially first trimester. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Albendazole is excreted in breast milk, caution is advised in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Albendazole has been extensively studied in various clinical trials for its efficacy against a wide range of parasitic infections, including those approved by regulatory bodies.
Lab Monitoring
- Liver function tests (baseline and every 2 weeks during extended therapy)
- Complete blood count (baseline and every 2 weeks during extended therapy)
Doctor Notes
- Advise patients to take with a fatty meal to maximize absorption.
- Monitor LFTs and CBC during extended treatment courses.
- Strictly avoid in the first trimester of pregnancy.
Patient Guidelines
- Take with food, especially a fatty meal.
- Chew the tablet completely before swallowing.
- Complete the full course of treatment as prescribed, even if you feel better.
- Inform your doctor if you are pregnant or planning to become pregnant.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double dose.
Driving Precautions
May cause dizziness or headache, so caution is advised when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Practice good hygiene to prevent reinfection.
- Wash hands thoroughly before meals and after using the toilet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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