Novelta-Power
Generic Name
Metronidazole
Manufacturer
Navana Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novelta power 500 mg suspension | ৳ 250.00 | N/A |
Description
Overview of the medicine
Novelta-Power 500 mg Suspension contains Metronidazole, an antibiotic and antiprotozoal medicine. It is used to treat a wide variety of bacterial and parasitic infections, including amebiasis, giardiasis, trichomoniasis, and bacterial vaginosis.
Uses & Indications
Dosage
Adults
Dosage varies widely based on indication. For general anaerobic infections: 500 mg orally every 8 hours. For amebiasis: 500-750 mg orally 3 times daily for 5-10 days. For children, dosage is calculated based on body weight.
Elderly
No specific dosage adjustment for elderly patients with normal hepatic and renal function. Caution with hepatic impairment.
Renal_impairment
Generally no dosage adjustment required for mild to moderate renal impairment. Caution and monitoring in severe renal failure or end-stage renal disease (ESRD).
How to Take
Take Novelta-Power 500 mg Suspension orally, with or after food, to minimize gastrointestinal upset. Shake the bottle well before each use. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Metronidazole is a prodrug. After entering anaerobic organisms, it is chemically reduced by ferredoxin or flavodoxin, forming reactive cytotoxic free radicals. These free radicals disrupt DNA synthesis and cause DNA damage, leading to cell death of susceptible bacteria and protozoa.
Pharmacokinetics
Onset
Varies depending on the infection type and severity.
Excretion
Mainly renal (60-80% of dose), some fecal excretion (6-15%).
Half life
Approximately 8 hours (range 6-12 hours).
Absorption
Well absorbed orally; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily hepatic, by oxidation with side-chain cleavage and glucuronide conjugation.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (relative contraindication, generally avoided unless absolutely necessary)
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing). Avoid alcohol during and for at least 3 days after treatment.
Lithium
Increases serum lithium levels, potentially leading to lithium toxicity. Monitor lithium levels.
Warfarin
Potentiates the anticoagulant effect of warfarin and other oral anticoagulants, increasing risk of bleeding. Close monitoring of INR is required.
Cimetidine
Prolongs metronidazole half-life by decreasing hepatic clearance, leading to increased metronidazole levels.
Phenobarbital/Phenytoin
Decreases metronidazole plasma levels by inducing hepatic enzymes.
Storage
Store below 30°C (86°F). Protect from light and moisture. Do not freeze. Keep out of reach of children. Discard any unused portion after the course of treatment or expiry date.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. There is no specific antidote. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion was recent.
Pregnancy & Lactation
Pregnancy Category B/C. Generally avoided in the first trimester. Use only if clearly needed and potential benefits outweigh risks. Metronidazole is excreted into breast milk; breastfeeding should be temporarily discontinued during treatment or an alternative drug should be used.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (relative contraindication, generally avoided unless absolutely necessary)
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing). Avoid alcohol during and for at least 3 days after treatment.
Lithium
Increases serum lithium levels, potentially leading to lithium toxicity. Monitor lithium levels.
Warfarin
Potentiates the anticoagulant effect of warfarin and other oral anticoagulants, increasing risk of bleeding. Close monitoring of INR is required.
Cimetidine
Prolongs metronidazole half-life by decreasing hepatic clearance, leading to increased metronidazole levels.
Phenobarbital/Phenytoin
Decreases metronidazole plasma levels by inducing hepatic enzymes.
Storage
Store below 30°C (86°F). Protect from light and moisture. Do not freeze. Keep out of reach of children. Discard any unused portion after the course of treatment or expiry date.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. There is no specific antidote. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion was recent.
Pregnancy & Lactation
Pregnancy Category B/C. Generally avoided in the first trimester. Use only if clearly needed and potential benefits outweigh risks. Metronidazole is excreted into breast milk; breastfeeding should be temporarily discontinued during treatment or an alternative drug should be used.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved (for Metronidazole)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Metronidazole has undergone extensive clinical trials validating its efficacy and safety across various bacterial and protozoal infections. Ongoing research explores new indications and resistance patterns.
Lab Monitoring
- Liver function tests (for prolonged high-dose therapy)
- Complete blood count (CBC) with differential (especially with prolonged therapy)
Doctor Notes
- Emphasize strict adherence to the complete course of treatment to minimize resistance development.
- Counsel patients on absolute alcohol avoidance during therapy and for at least 72 hours post-therapy due to disulfiram-like reactions.
- Monitor for neurological adverse effects, especially with prolonged use or high doses; discontinue if severe symptoms occur.
- Caution in patients with severe hepatic impairment; dose adjustment may be necessary.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve, to prevent recurrence and resistance.
- Avoid alcohol entirely during treatment and for at least 3 days after the last dose.
- Take with food to minimize stomach upset.
- Inform your doctor if you experience severe side effects or unusual symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Novelta-Power may cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating machinery or driving if these side effects occur.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- Stay hydrated by drinking plenty of fluids.
- Avoid self-medication and follow doctor's advice strictly.
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