Novotril
Generic Name
novotril-05-mg-tablet
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novotril 05 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Novotril 0.5 mg Tablet is used to treat anxiety disorders and panic disorder. It works by affecting brain chemicals that may be unbalanced in people with anxiety.
Uses & Indications
Dosage
Adults
Initial dose 0.25-0.5 mg, three times daily. May be increased up to a maximum of 4 mg daily in divided doses.
Elderly
Initial dose 0.25 mg, two or three times daily. Use with caution due to increased sensitivity and slower metabolism.
Renal_impairment
Use with caution. Dosage adjustments may be necessary based on individual patient response.
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
It enhances the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity, leading to a calming effect on the central nervous system.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted in the urine as metabolites.
Half life
11-12 hours (may range from 6 to 27 hours)
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to alprazolam or other benzodiazepines
- Acute narrow-angle glaucoma
- Concomitant use with ketoconazole, itraconazole
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Other CNS Depressants (e.g., alcohol, hypnotics, sedatives)
Additive CNS depressant effects.
CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, fluvoxamine, nefazodone)
Can significantly increase alprazolam plasma concentrations, requiring dosage reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management is symptomatic and supportive; flumazenil may be used as an antidote, but with caution due to the risk of seizures.
Pregnancy & Lactation
Should be avoided during pregnancy as it may cause fetal harm. Not recommended for use during lactation as it is excreted in breast milk and may cause sedation in the infant.
Side Effects
Contraindications
- Hypersensitivity to alprazolam or other benzodiazepines
- Acute narrow-angle glaucoma
- Concomitant use with ketoconazole, itraconazole
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Other CNS Depressants (e.g., alcohol, hypnotics, sedatives)
Additive CNS depressant effects.
CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, fluvoxamine, nefazodone)
Can significantly increase alprazolam plasma concentrations, requiring dosage reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management is symptomatic and supportive; flumazenil may be used as an antidote, but with caution due to the risk of seizures.
Pregnancy & Lactation
Should be avoided during pregnancy as it may cause fetal harm. Not recommended for use during lactation as it is excreted in breast milk and may cause sedation in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of alprazolam in the short-term treatment of anxiety and panic disorders. Studies have also explored its pharmacokinetics and interactions.
Lab Monitoring
- Liver function tests (periodically, especially with prolonged use or in patients with hepatic impairment)
Doctor Notes
- Prescribe for the shortest effective duration possible.
- Gradually taper dose when discontinuing to minimize withdrawal symptoms.
- Monitor patients for signs of abuse or dependence.
- Counsel patients on the risks of concomitant opioid use.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as withdrawal symptoms may occur.
- Avoid alcohol consumption while taking Novotril.
- Do not increase your dose or take it more often than prescribed.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Novotril may cause drowsiness, dizziness, or impaired coordination. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Incorporate stress management techniques such as meditation or yoga.
- Maintain a regular sleep schedule and ensure adequate rest.
- Engage in regular physical activity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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